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ChemInform Abstract: Noncovalent Inhibitors of Rhinovirus 3C Protease.
ChemInform, 2011AbstractFragment screening and structure—activity‐relationship exploration lead to identification of the first low micromolar, non‐covalent inhibitors of the human rhinovirus 3C protease.
Andy Morley, et al. et al.
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Isatin Compounds as Noncovalent SARS Coronavirus 3C-like Protease Inhibitors
Journal of Medicinal Chemistry, 2006A series of isatin derivatives were synthesized and tested against SARS CoV 3C-like protease. Substitutions at the N-1 and C-5 positions were examined to elucidate the differences in substrate binding sites of the rhinovirus 3C protease and SARS CoV 3C-like protease. Compound 5f shows significant inhibition with an IC(50) of 0.37 microM.
Lu, Zhou +7 more
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Kosmotropic Salt Activation and Substrate Specificity of Poliovirus Protease 3C
Biochemistry, 2006Picornaviruses produce a large polyprotein, which is cleaved by virally encoded cysteine peptidases, picornain-2A and -3C. Picornain-3C has characteristics of both the serine peptidase chymotrypsin and the cysteine peptidase papain in that the 3D structure resembles chymotrypsin, but its nucleophile is a cysteine SH rather than a serine OH group.
Gouvea, Iuri E. +7 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
Ca-A Cancer Journal for Clinicians, 2020Aaron J Grossberg +2 more
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Oral complications of cancer and cancer therapy
Ca-A Cancer Journal for Clinicians, 2012Joel B Epstein +2 more
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American Cancer Society Head and Neck Cancer Survivorship Care Guideline
Ca-A Cancer Journal for Clinicians, 2016Nader Sadeghi +2 more
exaly