Results 31 to 40 of about 405,626 (326)
Evaluation of DNA Vaccine Candidates against Foot-and-Mouth Disease Virus in Cattle
Vaccines, 2023 We evaluated four DNA vaccine candidates for their ability to produce virus-like particles (VLPs) and elicit a protective immune response against Foot-and-mouth disease virus (FMDV) in cattle.
Michael Puckette +4 more
doaj +1 more source
Activity of the Human Rhinovirus 3C Protease Studied in Various Buffers, Additives and Detergents Solutions for Recombinant Protein Production. [PDF]
PLoS ONE, 2016 Proteases are widely used to remove affinity and solubility tags from recombinant proteins to avoid potential interference of these tags with the structure and function of the fusion partner.
Raheem Ullah +7 more
doaj +1 more source
Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD. [PDF]
PLoS Pathogens, 2011 Toll-like receptor 3 (TLR3) and cytosolic RIG-I-like helicases (RIG-I and MDA5) sense viral RNAs and activate innate immune signaling pathways that induce expression of interferon (IFN) through specific adaptor proteins, TIR domain-containing adaptor ...
Lin Qu +6 more
doaj +1 more source
Vaccines, 2022 To improve the production of foot-and-mouth disease (FMD) molecular vaccines, we sought to understand the effects of the FMD virus (FMDV) 2B viroporin in an experimental, plasmid-based, virus-like particle (VLP) vaccine.
Victoria Primavera +4 more
doaj +1 more source
Seneca Valley Virus 3Cpro Cleaves PABPC1 to Promote Viral Replication
Pathogens, 2020 Seneca Valley Virus (SVV) is an oncolytic virus of the Picornaviridae family, which has emerged in recent years. The impact of SVV on host cell translation remains unknown.
Qiao Xue +5 more
doaj +1 more source
Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro. [PDF]
PLoS ONE, 2016 Luteoloside is a member of the flavonoids family that exhibits several bioactivities including anti-microbial and anti-cancer activities. However, the antiviral activity of luteoloside against enterovirus 71 (EV71) and the potential mechanism(s ...
Zeyu Cao +7 more
doaj +1 more source
Crystal Structure of Human Enterovirus 71 3C Protease [PDF]
Journal of Molecular Biology, 2011 Human enterovirus 71 (EV71) is the major pathogen that causes hand, foot and mouth disease that particularly affects young children. Growing hand, foot and mouth disease outbreaks were observed worldwide in recent years and caused devastating losses both economically and politically. However, vaccines or effective drugs are unavailable to date.
Cui, Sheng +8 more
openaire +2 more sources
Viruses, 2023 The Picornaviridae family comprises a large group of non-enveloped viruses with enormous impact on human and animal health. The picornaviral genome contains one open reading frame encoding a single polyprotein that can be processed by viral proteases ...
Somnath Mondal +2 more
doaj +1 more source
Crystal structure of the 3C protease from South African Territories type 2 foot-and-mouth disease virus [PDF]
, 2016 The replication of foot-and-mouth disease virus (FMDV) is dependent on the virus-encoded 3C protease (3Cpro). As in other picornaviruses, 3Cpro performs most of the proteolytic processing of the polyprotein expressed from the single open reading frame in
Curry, S, Leen, EN, Maree, FF, Yang, J
core +4 more sources
Association of EV71 3C polymorphisms with clinical severity
Journal of Microbiology, Immunology and Infection, 2018 Objectives: Enterovirus 71 (EV71) may cause neurological and fatal cases. EV71 3C plays an important role on viral replication and possess proteolysis activity.
Hsuan-Yin Ma +6 more
doaj +1 more source