Results 41 to 50 of about 405,626 (326)

RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage [PDF]

, 2009
Cytopathic viruses have developed successful strategies to block or, at least, to attenuate host interference with their replication. Here, we have analyzed the effects of poliovirus 2A protease on RNA nuclear export.
Carrasco Llamas, Luis, Castelló, Alfredo, Izquierdo, José M., Welnowska, Ewelina   +3 more
core   +1 more source

Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro. [PDF]

, 2018
Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds
Emmott, Edward, Goodfellow, Ian, Hosmillo, Myra, Kitano, Mitsutaka, Lu, Jia   +4 more
core   +1 more source

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses [PDF]

Journal of Virology, 2012
ABSTRACT Phylogenetic analysis has demonstrated that some positive-sense RNA viruses can be classified into the picornavirus-like supercluster, which includes picornaviruses, caliciviruses, and coronaviruses. These viruses possess 3C or 3C-like proteases (3Cpro or 3CLpro, respectively), which contain a typical chymotrypsin-like ...
Kim, Yunjeong, Lovell, Scott, Tiew, Kok-Chuan, Mandadapu, Sivakoteswara Rao, Alliston, Kevin R., Battaile, Kevin P., Groutas, William C., Chang, Kyeong-Ok   +7 more
openaire   +3 more sources

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]

, 2011
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson, Beenken, Bochukova, Burgar, Celli, Cohen, De Moerlooze, Duan, Duchesne, Ezzat, Fairbanks, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hanneken, Ibrahimi, Jang, Jang, Jang, John K. Heath, Jones, Kawano, Klein, Kuro-o, Lee M. Wheldon, Lewis, Maquat, McKeehan, Mendell, Meyers, Miki, Mohammad K. Hajihosseini, Muhlemann, Naila Khodabukus, Naski, Nelson, Oldridge, Peters, Polanska, Ricol, Saito, Sekine, Slaney, Smith, Susannah J. Patey, Takaishi, Tanimoto, Terada, Terence G. Smith, Tsang, Tsukuno, Werner, Wheldon, Wilkie, Yamaguchi, Zhang   +57 more
core   +3 more sources

Activation of Human Rhinovirus-14 3C Protease

Virology, 2001
The catalytic efficiency of human rhinovirus-14 (HRV14) 3C protease as a function of solvents and other regulators has been investigated using synthetic peptides as substrates. The proteolytic activity of HRV14 3C was found to be strongly stimulated by a series of anions in vitro and the activation was accompanied by changed Km, kcat, and increased ...
Wang, Q.May, Johnson, Robert B.
openaire   +2 more sources

Allosteric Functional Switch in Poliovirus 3C Protease [PDF]

Biophysical Journal, 2015
Viral genomes are very efficient; they are typically compact but nevertheless encode numerous elements that are essential for regulation of both its own replication and packaging, and of the host cell's machinery. Viruses have developed successful strategies to overcome their biological information storage problem.
Chan, Yan M., Boehr, David D.
openaire   +1 more source

Crystal structure of Senecavirus A 3C protease [PDF]

, 2020
AbstractSenecavirus A (SVA), an emerging picornavirus in porcine population, could infect porcines of all age group and cause FMD-like symptoms. Picornaviridae, a group of RNA viruses do harm to both human and stocks; however, most of picornaviruses are lack of effective vaccines and drugs.
Meng, Kaiwen, Zhang, Lijie, Meng, Geng
openaire   +1 more source

Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing.

PLoS Pathogens, 2023
RNA viruses cause numerous infectious diseases in humans and animals. The crosstalk between RNA viruses and the innate DNA sensing pathways attracts increasing attention.
Ya Yan, Lei Wu, Ye Yuan, Haiwei Wang, Hongyan Yin, Minjie Li, Lvye Chai, Ruiying Liang, Yanjie Liu, Dongming Zhao, Junji Xing, Pingwei Li, Xin Li   +12 more
doaj   +1 more source

Rational Discovery of Antiviral Whey Protein-Derived Small Peptides Targeting the SARS-CoV-2 Main Protease

Biomedicines, 2022
In the present work, and for the first time, three whey protein-derived peptides (IAEK, IPAVF, MHI), endowed with ACE inhibitory activity, were examined for their antiviral activity against the SARS-CoV-2 3C-like protease (3CLpro) and Human Rhinovirus 3C
Nicola Gambacorta, Leonardo Caputo, Laura Quintieri, Linda Monaci, Fulvio Ciriaco, Orazio Nicolotti   +5 more
doaj   +1 more source

Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation [PDF]

, 2017
The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and ...
Bulleid, Neil J., Pringle, Marie Anne, Robinson, Philip J., Woolhead, Cheryl A.   +3 more
core   +1 more source