Results 51 to 60 of about 916,340 (306)

3D CULTURE OF HaCaT KERATINOCYTE CELL LINE AS AN in vitro TOXICITY MODEL

Trakya University Journal of Natural Sciences, 2022
Ex vivo dermal toxicology analyses are crucial for replacement of in vivo test methods and have been of interest in recent years for testing cosmetics, drugs, and chemicals.
Fikrettin Şahin, Engin Sümer, Burçin Asutay, Derya Sağraç, Hatice Burcu Şişli, Binnur Kıratlı, Taha Bartu Hayal, Derya Burukçu, Selinay Şenkal, Ayşegül Doğan   +9 more
doaj   +1 more source

The XTT cell proliferation assay applied to cell layers embedded in three-dimensional matrix [PDF]

, 2012
Cell proliferation, a main target in cancer therapy, is influenced by the surrounding three-dimensional (3D) extracellular matrix (ECM). In vitro drug screening is, thus, optimally performed under conditions in which cells are grown (embedded or trapped)
Ampe, Christophe, Huyck, Lynn, Van Troys, Marleen   +2 more
core   +2 more sources

An Optically Controlled 3D Cell Culturing System [PDF]

Advances in OptoElectronics, 2011
A novel 3D cell culture system was developed and tested. The cell culture device consists of a microfluidic chamber on an optically absorbing substrate. Cells are suspended in a thermoresponsive hydrogel solution, and optical patterns are ...
Ishii, Kelly S., Hu, Wenqi, Namekar, Swapnil A., Ohta, Aaron T.   +3 more
openaire   +3 more sources

SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture [PDF]

, 2017
Multiple Myeloma (MM) is currently incurable despite many novel therapies. Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is a potential anti-tumour agent although effects as a single agent are limited.
A. Arhoma, A.D. Chantry, Abdulghani, Al-Yacoub, Amatangelo, Bladé, Deleu, Doi, Fandy, Fischbach, Geng, Herbst, Hideshima, Jelinek, Jian, Kagawa, Le Maitre, Lemancewicz, Matsui, Matthews, McStay, N.A. Cross, Niesvizky, Pan, Peterson, Rosato, S.L. Haywood-Small, Vitovski, von Pawel, Xu, Yamada, Younes, Zaravinos   +32 more
core   +1 more source

A Novel 3D Culture Model of Human ASCs Reduces Cell Death in Spheroid Cores and Maintains Inner Cell Proliferation Compared With a Nonadherent 3D Culture

Frontiers in Cell and Developmental Biology, 2021
3D cell culture technologies have recently shown very valuable promise for applications in regenerative medicine, but the most common 3D culture methods for mesenchymal stem cells still have limitations for clinical application, mainly due to the ...
Liang Luo, Wei Zhang, Jing Wang, Ming Zhao, Kuo Shen, Yanhui Jia, Yan Li, Jian Zhang, Weixia Cai, Dan Xiao, Xiaozhi Bai, Kaituo Liu, Kejia Wang, Yue Zhang, Huayu Zhu, Qin Zhou, Dahai Hu   +16 more
doaj   +1 more source

Alginate foam-based three-dimensional culture to investigate drug sensitivity in primary leukaemia cells [PDF]

, 2018
The development of assays for evaluating the sensitivity of leukaemia cells to anti-cancer agents is becoming an important aspect of personalized medicine.
Craig, D, Edirisinghe, M, Karimpoor, M, Khorashad, JS, Orlu, M, Parhizkar, M, Yebra-Fernandez, E   +6 more
core   +1 more source

Three-dimensional tissue scaffolds from interbonded poly(e-caprolactone) fibrous matrices with controlled porosity

, 2011
In this article, we report on the preparation and cell culture performance of a novel fibrous matrix that has an interbonded fiber architecture, excellent pore interconnectivity, and controlled pore size and porosity.
Kirkland, Mark, Lin, Tong, Sutti, Alessandra, Tang, Yanwei, Wang, Hongxia, Wang, Xungai, Wong, Cynthia   +6 more
core   +1 more source

Three-dimensional cell cultures as a new tool in drug discovery [PDF]

, 2016
Background and purpose: Producing of reliable information about pharmacological activity of new chemical entities is essential in early stages of drug discovery and development. There is a continuous need for improvement of existing in vitro technologies,
Dubravko Jelić, Ivo Zlatar, Karmen Brajša, Marija Trzun   +3 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cellular memory function from 3D to 2D: Three-dimensional high density collagen microfiber cultures induce their resistance to reactive oxygen species

Materials Today Bio
Cell properties generally change when the culture condition is changed. However, mesenchymal stem cells cultured on a hard material surface maintain their differentiation characteristics even after being cultured on a soft material surface.
Asuka Yamada, Shiro Kitano, Michiya Matsusaki   +2 more
doaj   +1 more source