3D genome structure reconstruction from chromosomal contact data
2021[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Different cell types of an organism have the same DNA sequence, but they can function differently because their difference in 3D organization allows them to express different genes and has different cellular functions.
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Artificial design of the genome: from sequences to the 3D structure of chromosomes
Trends in BiotechnologyGenome design is the foundation of genome synthesis, which provides a new platform for deepening our understanding of biological systems by exploring the fundamental components and structure of the genome. Artificial genome designs can endow unnatural genomes with desired functions.
Jun-Yi, Wang +4 more
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3D observation of chromosome scaffold structure using a 360° electron tomography sample holder
Micron, 2019The chromosome scaffold is considered to be a key structure of the mitotic chromosome. It plays a vital role in chromosome condensation, shaping the X-shaped structure of the mitotic chromosome, and also provides flexibility for chromosome movement during cell division.
Phengchat, Rinyaporn +4 more
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Long Noncoding RNAs May Alter Chromosome's 3D Structure
Science, 2013Abundant but mysterious molecules called long noncoding RNAs have long puzzled scientists, but some now think they could be influencing the shape of chromatin.
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Profiling Chromosome Topological Features by Super-Resolution 3D Structured Illumination Microscopy
Three-dimensional structured illumination microscopy (3D-SIM) and fluorescence in situ hybridization on three-dimensional preserved cells (3D-FISH) have proven to be robust and efficient methodologies for analyzing nuclear architecture and profiling the genome's topological features.Eunice, Fabian-Morales +4 more
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Chromosome 3D Structure Modeling and New Approaches For General Statistical Inference
2019This thesis consists of two separate topics, which include the use of piecewise helical models for the inference of 3D spatial organizations of chromosomes and new approaches for general statistical inference. The recently developed Hi-C technology enables a genome-wide view of chromosomespatial organizations, and has shed deep insights into genome ...
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Fast random algorithms for manifold based optimization in reconstructing 3D chromosomal structures
Communications in Information and Systems, 2021Duan Chen +3 more
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InterOmics - Reconstructing 3D chromatin structure from chromosome conformation capture data.
2015Dna is the central repository of information to keep cells and organisms alive. In human cells, the 46 chromosomes amount to a length of about 2 m, with a diameter of 2 nm, and are packed in a way that allows for access by transcription, replication and repair machinery, fitting within a globular nucleus with a radius of 5000 to 10000 nm. Efficiency of
Caudai C. +3 more
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Gene Regulation in Time and Space During X-Chromosome Inactivation
Nature Reviews Molecular Cell Biology, 2022Edith Heard +2 more
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Chromosome Organization in Bacteria: Mechanistic Insights Into Genome Structure and Function
Nature Reviews Genetics, 2020Remus T Dame +2 more
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