Results 91 to 100 of about 2,629,967 (312)

ARGV: 3D genome structure exploration using augmented reality

BMC Bioinformatics
Over the past two decades, scientists have increasingly realized the importance of the three-dimensional (3D) genome organization in regulating cellular activity.
Chrisostomos Drogaris, Yanlin Zhang, Eric Zhang, Elena Nazarova, Roman Sarrazin-Gendron, Sélik Wilhelm-Landry, Yan Cyr, Jacek Majewski, Mathieu Blanchette, Jérôme Waldispühl   +9 more
doaj   +1 more source

Vocabulaire 3D - Lexique pour les Sciences Humaines et Sociales

, 2020
"Ce document est le résultat d’un effort continu pour permettre aux acteurs des SHS et ceux de la 3D d’interagir autour d’un vocabulaire commun. Ce lexique a pour but d’accompagner les différents livrables du consortium 3D.
Consortium 3D SHS Team
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

3D genomics:

, 2022
DNA is stored in the nucleus of every cell in the same way, but how is this done? We show that the Cohesin-complex plays a major role in the formation and maintenance of chromatin-loops and that this affects multiple layers of gene-regulation.
openaire   +1 more source

SCW: building the whole-genome 3D structures based on extremely sparse single-cell Hi-C data

BMC Bioinformatics
Background The study of three-dimensional (3D) genome structures at the single-cell level is crucial for understanding cell-to-cell variability. However, it is challenging to reconstruct the 3D structures of the whole genome based on single-cell Hi-C ...
Hao Zhu, Tong Liu, Bishal Shrestha, Zheng Wang   +3 more
doaj   +1 more source

[Article] 3D digital recording of archaeological, architectural and artistic heritage

, 2020
3D DIGITAL RECORDING OF ARCHAEOLOGICAL, ARCHITECTURAL AND ARTISTIC HERITAGE
Consortium 3D SHS Team
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NanoLoop: A Deep Learning Framework Leveraging Nanopore Sequencing for Chromatin Loop Prediction

Advanced Science
Chromatin loops play a crucial role in gene regulation and cellular function, providing key insights into understanding the 3D structure of the genome and its impact on cellular homeostasis.
Wenjie Huang, Li Tang, Matthew C. Hill, Yonghao Zhang, Jun Xie, Min Li   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Studying 3D genome evolution using genomic sequence [PDF]

Bioinformatics, 2019
Abstract The 3D genome is essential to numerous key processes such as the regulation of gene expression and the replication-timing program. In vertebrates, chromatin looping is often mediated by CTCF, and marked by CTCF motif pairs in convergent orientation.
openaire   +3 more sources