Results 91 to 100 of about 5,528,770 (310)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes

Nature Communications
The eukaryotic nucleus exhibits a highly organized 3D genome architecture, with RNA transcription and processing confined to specific nuclear structures. While intra-chromosomal interactions, such as promoter-enhancer dynamics, are well-studied, the role
Claudia Rabuffo, Markus R. Schmidt, P. Yadav, Pin Tong, Roberta Carloni, Anna Barcons-Simon, Raúl O. Cosentino, Stefan Krebs, Keith R. Matthews, Robin C. Allshire, T. Siegel   +10 more
semanticscholar   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Acquisition, Modélisation, Préservation, Usages, ... des données 3D​: les challenges du Consortium 3D SHS

, 2020
"Le Consortium 3D SHS, labellisé en 2014 puis en 2018 par la TGIR Huma-Num, a pour vocation de fédérer les initiatives foisonnantes autour de la 3D pour les Sciences Humaines et Sociales pour définir des standards et des recommandations d'usage ainsi que
Consortium 3D SHS Team
core  

Initial Genomics of the Human Nucleolus [PDF]

, 2010
We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different ...
Laengst, Gernot, Santoyo-Lopez, Javier, Bálint Péterfia, Montaner David, Längst, Gernot, Conesa, Ana, Javier Santoyo-Lopez, Irina Solovei, Solovei, Irina, Dopazo, Joaquin, Cremer Thomas, Thomas Cremer, Joaquin Dopazo, Ignacio Medina, Nemeth, Attila, Medina, Ignacio, Längst Gernot, Akhtar, Asifa, Medina Ignacio, Németh Attila, Peterfia, Balint, Gernot Längst, Cremer, Thomas, Péterfia Bálint, Montaner, David, Solovei Irina, Attila Németh, Ana Conesa, Santoyo-Lopez Javier, Dopazo Joaquin, Conesa Ana, David Montaner   +31 more
core   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Share - Publish - Store - Preserve. Methodologies, Tools and Challenges for 3D Use in Social Sciences and Humanities

, 2020
"Through this White Paper, which gathers contributions from experts of 3D data as well as professionals concerned with the interoperability and sustainability of 3D research data, the PARTHENOS project aims at highlighting some of the current issues they
Consortium 3D SHS Team
core   +1 more source

3D genome organization contributes to genome instability at fragile sites

Nature Communications, 2020
Common fragile sites are regions susceptible to replication stress and are prone to chromosomal instability. Here, the authors, by analyzing the contribution of 3D chromatin organization, identify and characterize a fragility signature and precisely map ...
Dan Sarni, Takayo Sasaki, Michal Irony Tur-Sinai, Karin Miron, Juan Carlos Rivera-Mulia, Brian Magnuson, Mats Ljungman, David M. Gilbert, Batsheva Kerem   +8 more
doaj   +1 more source

Vocabulaire 3D - Lexique pour les Sciences Humaines et Sociales

, 2020
"Ce document est le résultat d’un effort continu pour permettre aux acteurs des SHS et ceux de la 3D d’interagir autour d’un vocabulaire commun. Ce lexique a pour but d’accompagner les différents livrables du consortium 3D.
Consortium 3D SHS Team
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source