Results 101 to 110 of about 392,690 (299)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An integrated multi-omics and network analysis of neutrophil differentiation from initial- to late-stage

Genome Biology
Background Neutrophil differentiation is a well-orchestrated process that involves coordinated changes in the chromatin accessibility, transcription factor (TF) binding, 3D genome-structure and transcription.
Qing Chen, Tianchang Yang, Yingping Hou, Kai Wang, Tingting Li, Longteng Wang, Cuiyun Dou, Panpan Cheng, Minglei Shi, Wei Li   +9 more
doaj   +1 more source

Studying 3D genome evolution using genomic sequence [PDF]

Bioinformatics, 2019
Abstract The 3D genome is essential to numerous key processes such as the regulation of gene expression and the replication-timing program. In vertebrates, chromatin looping is often mediated by CTCF, and marked by CTCF motif pairs in convergent orientation.
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations

, 2017
The Hi-C method is widely used to study the functional roles of the three-dimensional (3D) architecture of genomes. Here, we integrate Hi-C, whole-genome sequencing (WGS) and RNA-seq to study the 3D genome architecture of multiple myeloma (MM) and how it
Yifang Liu, Ruifeng Li, Ping Zhu, Tingting Li, Lumeng Jia, Yuezhou Yu, Cheng Li, Pengze Wu, Daiwei Tang, Qing Chen   +9 more
core   +1 more source

The genome of a pathogenic rhodococcus : cooptive virulence underpinned by key gene acquisitions [PDF]

, 2010
We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R.
Parkhill Julian, Cherevach, Inna, Iain Macarthur, Sanders Mandy, Leadon, Desmond, Prescott John F., Navas, Jesús, Michal Letek, González Patricia, Tom C. Freeman, Navas Méndez, Jesús, Valero-Rello, Ana, Ruth Fahey, Leadon Desmond, Bentley, Stephen D., Holdstock Jolyon, Ursula Fogarty, Scortti, Mariela M., Hapeshi, Alexia, José A. Vázquez-Boland, Inna Cherevach, Buckley, Tom, Rodríguez, Héctor M., Rodríguez Héctor, Ocampo Alain, Valero-Rello Ana, Fogarty Ursula, Valero Rello, Ana, Prescott, John F., Quail Michael A., Rodríguez, Héctor, Jolyon Holdstock, Alain Ocampo, Sanders, Mandy, Héctor Rodríguez, Fogarty, Ursula, Vázquez-Boland José A., Ana Valero-Rello, MacArthur Iain, Freeman Tom C., González, Patricia, Ocampo, Alain, Ana Valero-Rello, Fahey Ruth, Desmond Leadon, Cherevach Inna, Blanco, Mónica, Mariela M. Scortti, MacArthur, Iain, Vázquez Boland, José A., Bentley Stephen D., John F Prescott, Wim G. Meijer, Quail, Michael A., John F. Prescott, Stephen D. Bentley, Vázquez-Boland, José A., José A Vázquez-Boland, Holdstock, Jolyon, Stephen D Bentley, Letek Michal, Meijer, Wim G., Blanco Mónica, Meijer Wim G., Mónica Blanco, Ocampo Sosa, Alain Antonio, Tom C Freeman, Julian Parkhill, Jolyon Holdstock, Hapeshi Alexia, Tom Buckley, Wim G Meijer, Mandy Sanders, Michael A. Quail, Letek, Michal, Michael A Quail, Alexia Hapeshi, Scortti Mariela M., Parkhill, Julian, Navas Jesús, Patricia González, Mariela M Scortti, González, Patricia Jiménez, Buckley Tom, Freeman, Tom C., Fahey, Ruth, Jesús Navas   +86 more
core   +1 more source

sespesogil/SATB2_3D_Genome: SATB2 3D Genome

, 2023
<p>Code used for Wahl et al.2023</p> <p>Summary:</p> <p>The DNA-binding protein SATB2 is genetically linked to human intelligence.
sespesogil
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

3D genomics:

, 2022
DNA is stored in the nucleus of every cell in the same way, but how is this done? We show that the Cohesin-complex plays a major role in the formation and maintenance of chromatin-loops and that this affects multiple layers of gene-regulation.
openaire   +1 more source