Results 121 to 130 of about 5,528,770 (310)

Comparative 3D genome analysis between neural retina and retinal pigment epithelium reveals differential cis-regulatory interactions at retinal disease loci

Genome Biology
Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display specific spatiotemporal expression within these interconnected
E. D'Haene, Víctor López-Soriano, P. M. Martínez-García, Soraya Kalayanamontri, A. D. Rey, Ana Sousa-Ortega, Silvia Naranjo, S. Van de Sompele, Lies Vantomme, Q. Mahieu, S. Vergult, Ana Neto, J. Gómez-Skarmeta, J. Martínez-Morales, M. Bauwens, J. Tena, Elfride de Baere   +16 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

scGHOST: Identifying single-cell 3D genome subcompartments

Nature Methods
Single-cell Hi-C (scHi-C) technologies allow for probing of genome-wide cell-to-cell variability in three-dimensional (3D) genome organization from individual cells. Computational methods have been developed to reveal single-cell 3D genome features based
Kyle Xiong, Ruochi Zhang, Jian Ma
semanticscholar   +1 more source

Archéologie :imagerie numérique et 3D

, 2018
Participation du CST3D SHS au séminaire scientifique organisé par l'IRISA /INRAP. Juin 2018 , Paris. Les communications du séminaire se sont concentrées sur les apports heuristiques de la modélisation 3D et de l’imagerie ...
Consortium 3D SHS Team
core  

Aïoli, une plateforme d'annotation sémantique 3D pour la documentation collaborative d'objets patrimoniaux

, 2020
"Modéliser puis annoter un objet patrimonial en 3D à l’aide d’un simple smartphone, c’est ce que permet aujourd’hui le web service Aïoli développé au sein du laboratoire MAP ...."
Consortium 3D SHS Team
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Regulating epithelial-mesenchymal plasticity from 3D genome organization

Communications Biology
Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression.
Qing-You Pang, Yi-Chia Chiu, R. Huang
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Genetic–epigenetic interplay in the determination of plant 3D genome organization

Nucleic Acids Research
The 3D chromatin organization plays a major role in the control of gene expression. However, our comprehension of the governing principles behind nuclear organization remains incomplete.
Xiaoning He, Chloé Dias Lopes, Leonardo I. Pereyra-Bistraín, Ying Huang, Jing An, Rim Brik Chaouche, Hugo Zalzalé, Qingyi Wang, Xing Ma, Javier Antunez-Sanchez, Catherine Bergounioux, Sophie Piquerez, Sotirios Fragkostefanakis, Yijing Zhang, Shao-Jian Zheng, M. Crespi, Magdy M. Mahfouz, Olivier Mathieu, F. Ariel, J. Gutierrez-Marcos, Xing-Wang Li, Nicolas Bouché, C. Raynaud, D. Latrasse, M. Benhamed   +24 more
semanticscholar   +1 more source

Apport critique sur les matériels et logiciels 3D : Synthèse des outils et des technologies 3D

, 2020
"Le regroupement des différents partenaires du Consortium 3D SHS (Huma-Num) a été l’occasion de partager l’expertise et le savoir-faire - tant théorique que pratique - de ses membres, sur les modalités de production d’un objet numérique patrimonial.
Consortium 3D SHS Team
core