Results 121 to 130 of about 392,690 (299)

Dissecting the contribution of transposable elements to interphase chromosome structure

Genome Biology
Background Transposable elements (TEs) occupy nearly half of the human genome and play diverse biological roles. Despite their abundance, the extent to which TEs contribute to three-dimensional (3D) genome structure remains unclear.
Liyang Shi, Zhen Xiao, Xuemeng Zhou, Isaac A. Babarinde, Xiuling Fu, Gang Ma, Zhuoqi Huang, Li Sun, Jiangping He, Alexander Strunnikov, Andrew P. Hutchins   +10 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

ChromoTrace: Computational reconstruction of 3D chromosome configurations for super-resolution microscopy.

PLoS Computational Biology, 2018
The 3D structure of chromatin plays a key role in genome function, including gene expression, DNA replication, chromosome segregation, and DNA repair.
Carl Barton, Sandro Morganella, Øyvind Ødegård-Fougner, Stephanie Alexander, Jonas Ries, Tomas Fitzgerald, Jan Ellenberg, Ewan Birney   +7 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

3D Genome Architecture

, 2021
The tridimensional (3D) organization of the genome is just beginning to be understood and, despite the tremendous progress witnessed in the recent years, many essential questions remain unanswered. Major methodological and conceptual challenges need to be overcome to reach a comprehensive view of the physiological impact of 3D genome architecture in ...
Azorín, Ferran, Jordan, Albert, Maeso, Ignacio, Manzanares, Miguel, Rada-Iglesias, Alvaro, Roca, Joaquim, Rotllant, Josep, Vicent, Guillermo P.   +7 more
openaire   +1 more source

Supporting Focus and Context Awareness in 3D Modeling Using Multi-Layered Displays

, 2013
Although advances in computer technology over the past few decades have made it possible to create and render highly realistic 3D models these days, the process of creating these models has remained largely unchanged over the years.
Mohd Yusof, Azmi
core  

3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone

, 2011
The serum of Atlantic sea lamprey, a basal vertebrate, contains two corticosteroids, 11-deoxycortisol and deoxycorticosterone. Only 11-deoxycortisol has high affinity [Kd~3 nM] for the corticoid receptor [CR] in lamprey gill cytosol. To investigate the
Paiyuam Asnaashari, Michael E. Baker, Kayla Y. Uh   +2 more
core   +1 more source

Accelerating 3D genomics data analysis with Microcket

Communications Biology
The three-dimensional (3D) organization of genome is fundamental to cell biology. To explore 3D genome, emerging high-throughput approaches have produced billions of sequencing reads, which is challenging and time-consuming to analyze.
Yu Zhao, Mengqi Yang, Fanglei Gong, Yuqi Pan, Minghui Hu, Qin Peng, Leina Lu, Xiaowen Lyu, Kun Sun   +8 more
doaj   +1 more source

Evolutionary insights into 3D genome organization and epigenetic landscape of Vigna mungo

Life Science Alliance
By integrating SMRT long read, Hi-C, and Illumina pair-end sequencing technologies, we report a nearly complete, chromosomal-level assembly of V. mungo and characterize its 3D genome architecture.
Alim Junaid, Baljinder Singh, Sabhyata Bhatia   +2 more
doaj   +1 more source