Results 111 to 120 of about 392,690 (299)

Increasing power for voxel-wise genome-wide association studies : the random field theory, least square kernel machines and fast permutation procedures [PDF]

, 2012
Imaging traits are thought to have more direct links to genetic variation than diagnostic measures based on cognitive or clinical assessments and provide a powerful substrate to examine the influence of genetics on human brains. Although imaging genetics
Feng, Jianfeng, Ge, Tian, Hibar, Derrek P., Thompson, Paul M., Nichols, Thomas E.   +4 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Unraveling the 3D genome of human malaria parasites [PDF]

, 2019
The chromosomes within the eukaryotic cell nucleus are highly dynamic and adopt complex hierarchical structures. Understanding how this three-dimensional (3D) nuclear architectureaffects gene regulation, cell cycle progression and disease pathogenesis ...
Batugedara, Gayani, Le Roch, Karine G
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Comparative 3D genome organization in apicomplexan parasites

, 2019
The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and has a complex and dynamic relationship with gene expression.
Mamoun, CB, Andolina, C, Tewari, R, McGovern, KE, Tewari, Rita, Bunnik, Evelien M, Ross, Leila S, Ben Mamoun, Choukri, Venkat, A, Prudhomme, J, Lawres, L, Fidock, DA, Wilson, EH, Venkat, Aarthi, Galinski, Mary R, Worth, D, Sinnis, P, Brady, D, Nosten, F, Shao, Jianlin, Sinnis, Photini, Ross, LS, Lapp, SA, Ay, Ferhat, Le Roch, KG, Brady, Declan, Wilson, Emma H, Galinski, MR, Le Roch, Karine G, Lapp, Stacey A, Ay, F, Andolina, Chiara, Batugedara, Gayani, Shao, J, Lawres, Lauren, Nosten, Francois, Bunnik, EM, Batugedara, G, McGovern, Kathryn E, Worth, Danielle, Prudhomme, Jacques, Fidock, David A   +41 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Deciphering histone mark-specific fine-scale chromatin organization at high resolution with Micro-C-ChIP

Nature Communications
The regulation of cell-type-specific transcription relies on complex 3D interactions between promoters and distal regulatory elements. Although Hi-C has advanced our understanding of genome architecture, its high sequencing demand limits use in large ...
Mariia Metelova, Maria Louisa Vigh, Nils Krietenstein   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Genome 3D Viewer: A 3D Model Of The Human Genome Using Unity 3D

, 2016
The 3D Genome viewer is a 3D model of the Human Genome rendered using the Unity Game Engine that allows the user to manipulate the image as if going through a video game.
Dickson-Vandervelde, Frances
core  

Principles of the 3D genome organization in malaria mosquitoes

, 2020
Poster "Principles of the 3D genome organization in malaria mosquitoes.
Varvara Lukyanchikova (8713636), Veniamin S. Fishman (3915167), Igor Sharakhov (5941565), Nariman R. Battulin (3915170), Alexander Tyapkin (8726452), Polina Belokopytova (8726454), Miroslav Nuriddinov (8726448)   +6 more
core   +1 more source