Results 211 to 220 of about 388,478 (262)

3D genome folding in epigenetic regulation and cellular memory. [PDF]

Trends Cell Biol
Paldi F, Cavalli G.
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Deciphering chromatin domain, domain community and chromunity for 3D genome maps with Mactop. [PDF]

Commun Biol
Duan R, Dang D, Fan S, Yao S, Zhang S.
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

H3K27 and H3K9 methylation mask potential CTCF binding sites to maintain 3D genome integrity. [PDF]

Genome Res
Fukuda K, Shimura C, Shinkai Y.
europepmc   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

3D Genome Architecture in Stem Cell Lineage Commitment: from Structural Organization to Precision Regulation. [PDF]

Adv Genet (Hoboken)
He Y, Li W, Li L, Yang Y, Lu Y, Pan Y, Wang Q, Sun Y, Xie Y, Wu M, Luo P, Sun W, Zhang H.   +12 more
europepmc   +1 more source

Modelling transcriptional silencing and its coupling to 3D genome organisation.

Soft Matter
Semeraro M, Negro G, Marenduzzo D, Forte G.   +3 more
europepmc   +1 more source

Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organization. [PDF]

NAR Genom Bioinform
Tamon L, Fahmi Z, Ashford J, Collepardo-Guevara R, Sahakyan AB.   +4 more
europepmc   +1 more source