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Chinese Science Bulletin, 2014
It is already more than 10 years after the completion of Human Genome Project. However, the mechanism about how genomic information guides the gene expression in a particular space and time remains to be elucidated. Structure determines function is a consensus that we understand the laws of nature.
ShengMing DU +3 more
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It is already more than 10 years after the completion of Human Genome Project. However, the mechanism about how genomic information guides the gene expression in a particular space and time remains to be elucidated. Structure determines function is a consensus that we understand the laws of nature.
ShengMing DU +3 more
openaire +1 more source
Advances in technologies for 3D genomics research
Science China Life Sciences, 2020The spatial structure of the orderly organized chromatin in the nucleus has important roles in maintaining normal cell function and in regulation of gene expression, and the high-throughput Hi-C and ChIA-PET methods have been widely used in various biological studies for determining potential spatial genome structures and their functions.
Yan, Zhang, Guoliang, Li
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The 3D Genome as a Target for Anticancer Therapy
Trends in Molecular Medicine, 2020The role of 3D genome organization in the precise regulation of gene expression is well established. Accordingly, the mechanistic connections between 3D genome alterations and disease development are becoming increasingly apparent. This opinion article provides a snapshot of our current understanding of the 3D genome alterations associated with cancers.
Omar L, Kantidze +3 more
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3D genome and its disorganization in diseases
Cell Biology and Toxicology, 2018The chromosomes in eukaryotic cells are highly folded and organized to form dynamic three-dimensional (3D) structures. In recent years, many technologies including chromosome conformation capture (3C) and 3C-based technologies (Hi-C, ChIA-PET) have been developed to investigate the 3D structure of chromosomes.
Ruifeng, Li +5 more
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The 3D Genome: EZH2 Comes into the Fold
Trends in Molecular Medicine, 2019EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, https://doi.org/10.1038/s41588-018-0338-y) examined the effects of mutant EZH2 on the ...
Gerard L, Brien, Adrian P, Bracken
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Nature Methods, 2009
Refinements in methods to uncover the higher-order structure of the genome will allow functional insight into genomic architecture at high resolution.
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Refinements in methods to uncover the higher-order structure of the genome will allow functional insight into genomic architecture at high resolution.
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An uneven race: genome editing for parasitic worms
Nature Reviews Microbiology, 2021Geetha Sankaranarayanan +2 more
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