Results 221 to 230 of about 388,478 (262)

Transcriptional condensates and the nuclear pore complex regulate gene expression and 3D genome architecture in response to stress. [PDF]

Biochem Soc Trans
Mohajan S, Gross DS.
europepmc   +1 more source

Genome Mountaineering: Expanding Horizons of the 3D Genome for the Intrepid Evolutionary Adventurer. [PDF]

Genome Biol Evol
Mackay-Smith A, Wray GA.
europepmc   +1 more source

Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue. [PDF]

Nat Genet
Chen ZJ, Das SS, Kar A, Lee SHT, Abuhanna KD, Alvarez M, Sukhatme MG, Wang Z, Gelev KZ, Heffel MG, Zhang Y, Avram O, Rahmani E, Sankararaman S, Laakso M, Heinonen S, Peltoniemi H, Halperin E, Pietiläinen KH, Luo C, Pajukanta P.   +20 more
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Genome reorganisation and expansion shape 3D genome architecture and define a distinct regulatory landscape in coleoid cephalopods

Rogers TF, Stock J, Schulz NG, Yalçin G, Rencken S, Weissenbacher A, Clarence T, Schultz DT, Ragsdale CW, Albertin CB, Simakov O.   +10 more
europepmc   +1 more source

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3D or Not 3D: Shaping the Genome during Development

Cold Spring Harbor Perspectives in Biology, 2021
One of the most fundamental questions in developmental biology is how one fertilized cell can give rise to a fully mature organism and how gene regulation governs this process. Precise spatiotemporal gene expression is required for development and is believed to be achieved through a complex interplay of sequence-specific information, epigenetic ...
Glaser, J. ; https://orcid.org/0000-0001-6745-6924, Mundlos, S. ; https://orcid.org/0000-0002-9788-3166   +1 more
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3D Genomics

Molecular Biology, 2019
The development of new research methods significantly changed our views on the role that the 3D organization of the genome plays in its functional activity. It was found that the genome is subdivided into structural-functional units that restrict the area of enhancer action at the level of spatial organization.
S V, Razin, S V, Ulianov, A A, Gavrilov
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Mechanical forces and the 3D genome

Current Opinion in Structural Biology, 2023
Traditionally, the field of genomics has been studied from a biochemical perspective. Besides chemical influences, cells are subject to a variety of mechanical signals from their surrounding tissue microenvironment. These mechanical signals can not only cause changes to a cell's physical structure but can also lead to alterations in their genomes and ...
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Organization and function of the 3D genome

Nature Reviews Genetics, 2016
Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology. Despite spectacular progress in this field, we still know remarkably little about the mechanisms underlying chromatin structure and how it can be established, reset ...
Bonev, B, Cavalli, Giacomo
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Expanding the toolbox for 3D genomics

Nature Genetics, 2018
The ability to visualize and study the 3D folding of chromosomes in cells has been propelled forward by several major technological advances in the past two decades. Two new studies now further expand the scientific toolbox for studying chromosome conformation by providing novel methodologies for accurate mapping of genome topology and predicting the ...
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