Results 61 to 70 of about 5,528,770 (310)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis

Frontiers in Genetics, 2023
Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS ...
Connor Davidson, Connor Davidson, B. Paul Wordsworth, Carla J. Cohen, Carla J. Cohen, Julian C. Knight, Matteo Vecellio, Matteo Vecellio   +7 more
doaj   +1 more source

GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells

Nature Genetics
The organization of mammalian genomes features a complex, multiscale three-dimensional (3D) architecture, whose functional significance remains elusive because of limited single-cell technologies that can concurrently profile genome organization and ...
Tianming Zhou, Ruochi Zhang, Deyong Jia, R. Doty, A. Munday, Daniel Gao, Li Xin, Janis L. Abkowitz, Zhijun Duan, Jian Ma   +9 more
semanticscholar   +1 more source

Structural Variations in Cancer and the 3D Genome

Nature Reviews. Cancer, 2022
Structural variations (SVs) affect more of the cancer genome than any other type of somatic genetic alteration but difficulties in detecting and interpreting them have limited our understanding. Clinical cancer sequencing also increasingly aims to detect
F. Dubois, N. Sidiropoulos, J. Weischenfeldt, R. Beroukhim   +3 more
semanticscholar   +1 more source

3D HOP

, 2020
" 3DHOP (3D Heritage Online Presenter) is an open-source software package for the creation of interactive Web presentations of high-resolution 3D models, oriented to the Cultural Heritage field....
Consortium 3D SHS Team
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reconstruct high-resolution 3D genome structures for diverse cell-types using FLAMINGO

Nature Communications, 2022
High-resolution reconstruction of spatial chromosome organisation is in demand. Here the authors report FLAMINGO, for reconstructing high-resolution 3D Genome Organisation from HiC data which they use to generate both 5 kb and 1 kb-resolution 3D ...
Hao Wang, Jiaxin Yang, Yu Zhang, Jianliang Qian, Jianrong Wang   +4 more
doaj   +1 more source

Rewiring cancer: 3D genome determinants of cancer hallmarks

Current Opinion in Genetics and Development
In modern cancer biology, Hanahan and Weinberg’s classic depiction of the Hallmarks of Cancer serves as a heuristic for understanding malignant phenotypes[1].
M. E. Amodeo, Christine E. Eyler, Sarah E Johnstone   +2 more
semanticscholar   +1 more source

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

Nature Communications, 2023
Nearly 70% of Uterine fibroid (UF) tumors are driven by recurrent MED12 hotspot mutations. Unfortunately, no cellular models could be generated because the mutant cells have lower fitness in 2D culture conditions.
Kadir Buyukcelebi, Xintong Chen, Fatih Abdula, Hoda Elkafas, A. Duval, Harun Ozturk, Fidan Seker-Polat, Qiu-Shi Jin, Ping Yin, Yue-Qing Feng, S. Bulun, Jian-Jun Wei, Feng Yue, Mazhar Adli   +13 more
semanticscholar   +1 more source

Conservatoire des Données 3D SHS

, 2020
” Le Conservatoire National des Données 3D SHS est un environnement de sauvegarde sécurisé pour les données 3D, soutenu par Huma-Num.. …
Consortium 3D SHS Team
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source