Results 51 to 60 of about 5,528,770 (310)
MyoD is a 3D genome structure organizer for muscle cell identity
Nature Communications, 2022 The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each cell type has a unique 3D genome organization that determines its cell identity.
Rui-chen Wang +19 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Three-dimensional genome architecture and emerging technologies: looping in disease
Genome Medicine, 2017 Genome compaction is a universal feature of cells and has emerged as a global regulator of gene expression. Compaction is maintained by a multitude of architectural proteins, long non-coding RNAs (lncRNAs), and regulatory DNA.
Arpit Mishra, R. David Hawkins
doaj +1 more source
3D genome-selected microRNAs to improve Alzheimer's disease prediction
Frontiers in Neurology, 2023 IntroductionAlzheimer's disease (AD) is a type of neurodegenerative disease that has no effective treatment in its late stage, making the early prediction of AD critical. There have been an increase in the number of studies indicating that miRNAs play an
Keyi Li +14 more
doaj +1 more source
High-throughput Oligopaints identifies druggable 3D genome regulators
Nature, 2023 High-throughput DNA or RNA labelling with optimized Oligopaints (HiDRO) reveals more than 300 factors that influence genome folding during interphase, including 43 genes that were validated as either increasing or decreasing interactions between ...
Daniel S. Park +20 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Toward understanding the dynamic state of 3D genome
Computational and Structural Biotechnology Journal, 2020 The three-dimensional (3D) genome organization and its role in biological activities have been investigated for over a decade in the field of cell biology.
Soya Shinkai +2 more
doaj +1 more source
Cell type–specific 3D-genome organization and transcription regulation in the brain
Science Advances3D organization of the genome plays a critical role in regulating gene expression. How 3D-genome organization differs among different cell types and relates to cell type–dependent transcriptional regulation remains unclear. Here, we used genome-scale DNA
Shiwei Liu +8 more
semanticscholar +1 more source
Cell-type-specific 3D-genome organization and transcription regulation in the brain
bioRxiv, 2023 3D organization of the genome plays a critical role in regulating gene expression. However, it remains unclear how chromatin organization differs among different cell types in the brain.
Shiwei Liu +6 more
semanticscholar +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source