Results 41 to 50 of about 5,528,770 (310)
[Logiciel] Open source 3D viewer
, 2021 "Voyager is part of the Smithsonian’s Digitization Program Office’s 3D foundation pipeline.
Consortium 3D SHS Team
core
The 3D Genome: From Structure to Function
, 2021 The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and
Ahmed Al-Harrasi +2 more
core +1 more source
3D Genome Engineering: Current Advances and Therapeutic Opportunities in Human Diseases
ResearchDynamic chromatin 3-dimensional (3D) conformation is a key mechanism regulating gene expression and cellular function during development and disease.
Xing Jiang +4 more
doaj +1 more source
bioRxivChanges in gene regulation were a major driver of the divergence of archaic hominins (AHs)—Neanderthals and Denisovans—and modern humans (MHs). The three-dimensional (3D) folding of the genome is critical for regulating gene expression; however, its role
Evonne McArthur +11 more
semanticscholar +1 more source
Nucleic Acids Research, 2023 The human brain is a complex organ comprised of distinct cell types, and the contribution of the 3D genome to lineage specific gene expression remains poorly understood.
Samir Rahman +14 more
semanticscholar +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cell Reports, 2023 Special AT-rich sequence binding protein 1 (SATB1) has long been proposed to act as a global chromatin loop organizer in T cells. However, the exact functions of SATB1 in spatial genome organization remain elusive.
Bao Wang, Lu-Zhang Ji, Q. Bian
semanticscholar +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Nature Communications, 2023 The interphase genome is dynamically organized in the nucleus and decorated with chromatin-associated RNA (caRNA). It remains unclear whether the genome architecture modulates the spatial distribution of caRNA and vice versa. Here, we generate a resource
Riccardo Calandrelli +18 more
doaj +1 more source
Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples
Science AdvancesGlioblastoma (GBM) is the most prevalent malignant brain tumor with poor prognosis. Although chromatin intratumoral heterogeneity is a characteristic feature of GBM, most current studies are conducted at a single tumor site.
Qi-Xuan Wang +15 more
semanticscholar +1 more source