Results 31 to 40 of about 392,690 (299)
3D genome organization and epigenetic regulation in autoimmune diseases
Frontiers in Immunology, 2023 Three-dimensional (3D) genomics is an emerging field of research that investigates the relationship between gene regulatory function and the spatial structure of chromatin.
Yueqi Qiu +13 more
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Initial Genomics of the Human Nucleolus [PDF]
, 2010 We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human genome and identified different ...
Laengst, Gernot +31 more
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Nature Methods, 2016 DNA folding shapes gene expression. Emerging techniques promise to reveal the intricacies of this architectural language of chromosomes.
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Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
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3D Genome Tuner: Compare Multiple Circular Genomes in a 3D Context
Genomics, Proteomics & Bioinformatics, 2009 Abstract Circular genomes, being the largest proportion of sequenced genomes, play an important role in genome analysis. However, traditional 2D circular map only provides an overview and annotations of genome but does not offer feature-based comparison. For remedying these shortcomings, we developed 3D Genome Tuner, a hybrid of circular
Qi Wang 0072, Qun Liang, Xiuqing Zhang
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Interplay of lamin A and lamin B LADs on the radial positioning of chromatin
Nucleus, 2019 Immunosuppressive drugs such as cyclosporin A (CsA) can elicit hepatotoxicity by affecting gene expression. Here, we address the link between CsA and large-scale chromatin organization in HepG2 hepatocarcinoma cells.
Frida Forsberg +3 more
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Enhancer Function in the 3D Genome
Genes, 2023 In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space.
Sergey V. Razin +2 more
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Principles of 3D Compartmentalization of the Human Genome [PDF]
Cell Reports, 2020 Abstract Chromatin is organized in the nucleus by CTCF loops and compartmental domains, the latter of which contain sequences bound by proteins capable of mediating interactions among themselves. While compartmental domains are one of the most prominent features of genome 3D organization at the chromosome scale, we ...
Michael H. Nichols, Victor G. Corces
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keiserlab/3d-genome-disruption-paper: v1. 0
, 2023 First publication ...
michael keiser, Laura Gunsalus
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The era of 3D and spatial genomics
Trends in Genetics, 2022 Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C) sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D genome has flourished, enabling an ever-increasing understanding of how DNA is packaged in the nucleus and how the spatiotemporal organization of the genome orchestrates its vital ...
Bouwman, Britta A.M. +2 more
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