Results 31 to 40 of about 388,478 (262)
From association to mechanism in complex disease genetics: the role of the 3D genome
Arthritis Research & Therapy, 2018 Genome-wide association studies (GWAS) and fine mapping studies in autoimmune diseases have identified thousands of genetic variants, the majority of which are located in non-protein-coding enhancer regions.
Yao Fu +3 more
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DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency
Cell Reports, 2019 Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its target ...
Katy McLaughlin +11 more
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Optoepigenetics for 3D genome engineering [PDF]
Nature Reviews Genetics, 2019 A study in Nature Methods describes a light-activated dynamic looping (LADL) system, which consists of a synthetic architectural protein that rapidly induces long-range chromatin interactions in response to blue light.
openaire +2 more sources
Manifold Based Optimization for Single-Cell 3D Genome Reconstruction. [PDF]
PLoS Computational Biology, 2015 The three-dimensional (3D) structure of the genome is important for orchestration of gene expression and cell differentiation. While mapping genomes in 3D has for a long time been elusive, recent adaptations of high-throughput sequencing to chromosome ...
Jonas Paulsen +2 more
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Integrating Transposable Elements in the 3D Genome [PDF]
Mobile DNA, 2019 Chromosome organisation is increasingly recognised as an essential component of genome regulation, cell fate and cell health. Within the realm of transposable elements (TEs) however, the spatial information of how genomes are folded is still only rarely integrated in experimental studies or accounted for in modelling.
Bousios, Alexandros +3 more
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Enhancers dysfunction in the 3D genome of cancer cells
Frontiers in Cell and Developmental Biology, 2023 Eukaryotic genomes are spatially organized inside the cell nucleus, forming a threedimensional (3D) architecture that allows for spatial separation of nuclear processes and for controlled expression of genes required for cell identity specification and ...
Giulia Della Chiara +8 more
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Enhancer Dysfunction in 3D Genome and Disease [PDF]
Cells, 2019 Spatiotemporal patterns of gene expression depend on enhancer elements and other factors during individual development and disease progression. The rapid progress of high-throughput techniques has led to well-defined enhancer chromatin properties.
Ji-Han Xia, Gong-Hong Wei
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A novel neoantigen discovery approach based on chromatin high order conformation
BMC Medical Genomics, 2020 Background High-throughput sequencing technology has yielded reliable and ultra-fast sequencing for DNA and RNA. For tumor cells of cancer patients, when combining the results of DNA and RNA sequencing, one can identify potential neoantigens that ...
Yi Shi +15 more
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Structural variations in cancer and the 3D genome
Nature Reviews Cancer, 2022 Structural variations (SVs) affect more of the cancer genome than any other type of somatic genetic alteration but difficulties in detecting and interpreting them have limited our understanding. Clinical cancer sequencing also increasingly aims to detect SVs, leading to a widespread necessity to interpret their biological and clinical relevance ...
Frank Dubois +3 more
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source