Results 11 to 20 of about 392,690 (299)
3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome [PDF]
Nucleic Acids Research, 2020 Abstract Three-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, various types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic gene expression.
Kyukwang Kim +6 more
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3D or Not 3D: Shaping the Genome during Development
Cold Spring Harbor Perspectives in Biology, 2021 One of the most fundamental questions in developmental biology is how one fertilized cell can give rise to a fully mature organism and how gene regulation governs this process. Precise spatiotemporal gene expression is required for development and is believed to be achieved through a complex interplay of sequence-specific information, epigenetic ...
Glaser, J. ; https://orcid.org/0000-0001-6745-6924 +1 more
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Gene regulation in the 3D genome [PDF]
Human Molecular Genetics, 2018 The spatial organization of the genome is essential for the precise control of gene expression. Recent advances in sequencing and imaging technologies allow us to explore the 3D genome and its relationship to gene regulation at an unprecedented scale.
Yun, Li, Ming, Hu, Yin, Shen
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Structural variation in the 3D genome [PDF]
Nature Reviews Genetics, 2018 Structural and quantitative chromosomal rearrangements, collectively referred to as structural variation (SV), contribute to a large extent to the genetic diversity of the human genome and thus are of high relevance for cancer genetics, rare diseases and evolutionary genetics.
Malte Spielmann +2 more
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The 3D Genome in Transcriptional Regulation and Pluripotency [PDF]
Cell Stem Cell, 2014 It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism's genetic blueprint. However, the genome does not exist as a linear entity within cells where this blueprint is actually utilized.
Gorkin, David U. +2 more
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Enhancers dysfunction in the 3D genome of cancer cells [PDF]
Frontiers in Cell and Developmental Biology, 2023 Eukaryotic genomes are spatially organized inside the cell nucleus, forming a threedimensional (3D) architecture that allows for spatial separation of nuclear processes and for controlled expression of genes required for cell identity specification and ...
Giulia Della Chiara +8 more
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3D genome organization and its study in livestock breeding
Journal of Integrative AgricultureEukaryotic genomes are hierarchically packaged into cell nucleus, affecting gene regulation. The genome is organized into multiscale structural units, including chromosome territories, compartments, topologically associating domains (TADs), and DNA loops.
Jie Cheng +9 more
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Enhancer Dysfunction in 3D Genome and Disease [PDF]
Cells, 2019 Spatiotemporal patterns of gene expression depend on enhancer elements and other factors during individual development and disease progression. The rapid progress of high-throughput techniques has led to well-defined enhancer chromatin properties.
Ji-Han Xia, Gong-Hong Wei
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UV-induced reorganization of 3D genome mediates DNA damage response
Nature CommunicationsWhile it is well-established that UV radiation threatens genomic integrity, the precise mechanisms by which cells orchestrate DNA damage response and repair within the context of 3D genome architecture remain unclear.
Veysel Oğulcan Kaya, Ogün Adebali
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Genome Biology, 2018 Here, we introduce the 3D Genome Browser, http://3dgenome.org, which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types.
Yanli Wang +12 more
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