Results 11 to 20 of about 5,528,770 (310)

Novel biological insights revealed from the investigation of multiscale genome architecture

Computational and Structural Biotechnology Journal, 2023
Gene expression and cell fate determination require precise and coordinated epigenetic regulation. The complex three-dimensional (3D) genome organization plays a critical role in transcription in myriad biological processes. A wide range of architectural
Tianyi Ding, He Zhang
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DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity

Cell Reports, 2021
Summary: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects ...
Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena Zotenko, Cathryn M. Gould, Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark   +23 more
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Hetero-deformation-induced stress in additively manufactured 316L stainless steel

Materials Research Letters, 2020
Heterogeneous cellular structure combined with bimodal grain structure contributed to the high hetero-deformation-induced (HDI) stress in selective laser melted 316L stainless steel (SLMed 316L SS) and high grain boundary density at molten pool ...
Decheng Kong, Chaofang Dong, Xiaoqing Ni, Zhang Liang, Cheng Man, Xiaogang Li   +5 more
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Three‐dimensional genome structure and function

MedComm, 2023
Linear DNA undergoes a series of compression and folding events, forming various three‐dimensional (3D) structural units in mammalian cells, including chromosomal territory, compartment, topologically associating domain, and chromatin loop.
Hao Liu, Hsiangyu Tsai, Maoquan Yang, Guozhi Li, Qian Bian, Gang Ding, Dandan Wu, Jiewen Dai   +7 more
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3D genome organization and epigenetic regulation in autoimmune diseases

Frontiers in Immunology, 2023
Three-dimensional (3D) genomics is an emerging field of research that investigates the relationship between gene regulatory function and the spatial structure of chromatin.
Yueqi Qiu, Yueqi Qiu, Delong Feng, Wenjuan Jiang, Wenjuan Jiang, Tingting Zhang, Tingting Zhang, Tingting Zhang, Qianjin Lu, Qianjin Lu, Qianjin Lu, Ming Zhao, Ming Zhao, Ming Zhao   +13 more
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Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

Cell, 2023
Summary Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark of neurodegenerative diseases including Alzheimer’s Disease (AD), with the potential to disrupt genome integrity.
Vishnu Dileep, Carles A. Boix, Hansruedi Mathys, A. Marco, Gwyneth M. Welch, Hiruy S Meharena, Anjanet Loon, Ritika Jeloka, Zhuyu Peng, David A. A. Bennett, M. Kellis, Li-Huei Tsai   +11 more
semanticscholar   +1 more source

Role of lamins in 3D genome organization and global gene expression

Nucleus, 2019
Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
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Interplay of lamin A and lamin B LADs on the radial positioning of chromatin

Nucleus, 2019
Immunosuppressive drugs such as cyclosporin A (CsA) can elicit hepatotoxicity by affecting gene expression. Here, we address the link between CsA and large-scale chromatin organization in HepG2 hepatocarcinoma cells.
Frida Forsberg, Annaël Brunet, Tharvesh M. Liyakat Ali, Philippe Collas   +3 more
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Multiscale 3D Genome Rewiring during Mouse Neural Development

Cell, 2017
Summary Chromosome conformation capture technologies have revealed important insights into genome folding. Yet, how spatial genome architecture is related to gene expression and cell fate remains unclear.
B. Bonev, Netta Mendelson Cohen, Quentin Szabo, Lauriane Fritsch, G. Papadopoulos, Yaniv Lubling, Xiaole Xu, Xiaodan Lv, J. Hugnot, A. Tanay, Giacomo Cavalli   +10 more
semanticscholar   +1 more source

Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus

Cell, 2018
SUMMARY Eukaryotic genomes are packaged into a three-dimensional structure in the nucleus. Current methods for studying genome-wide structure are based on proximity-ligation.
Sofia A. Quinodoz, Noah Ollikainen, B. Tabak, Ali Palla, J. Schmidt, Elizabeth Detmar, M. Lai, Alexander A. Shishkin, Prashant Bhat, Yodai Takei, Vickie Trinh, E. Aznauryan, Pamela Russell, Christine S. Cheng, M. Jovanović, A. Chow, L. Cai, P. McDonel, M. Garber, M. Guttman   +19 more
semanticscholar   +1 more source