Results 11 to 20 of about 388,478 (262)
The Hierarchy of the 3D Genome [PDF]
Molecular Cell, 2013 Mammalian genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Transcriptional control involves the establishment of physical connections among genes and regulatory elements, both along and between chromosomes.
Gibcus, Johan H, Dekker, Job
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3D genomic organization in cancers
Quantitative Biology, 2023 BackgroundThe hierarchical three‐dimensional (3D) architectures of chromatin play an important role in fundamental biological processes, such as cell differentiation, cellular senescence, and transcriptional regulation. Aberrant chromatin 3D structural alterations often present in human diseases and even cancers, but their underlying mechanisms remain ...
Junting Wang 0003 +4 more
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Gene regulation in the 3D genome [PDF]
Human Molecular Genetics, 2018 The spatial organization of the genome is essential for the precise control of gene expression. Recent advances in sequencing and imaging technologies allow us to explore the 3D genome and its relationship to gene regulation at an unprecedented scale.
Yun, Li, Ming, Hu, Yin, Shen
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Hetero-deformation-induced stress in additively manufactured 316L stainless steel
Materials Research Letters, 2020 Heterogeneous cellular structure combined with bimodal grain structure contributed to the high hetero-deformation-induced (HDI) stress in selective laser melted 316L stainless steel (SLMed 316L SS) and high grain boundary density at molten pool ...
Decheng Kong +5 more
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Three‐dimensional genome structure and function
MedComm, 2023 Linear DNA undergoes a series of compression and folding events, forming various three‐dimensional (3D) structural units in mammalian cells, including chromosomal territory, compartment, topologically associating domain, and chromatin loop.
Hao Liu +7 more
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3D genome organization and epigenetic regulation in autoimmune diseases
Frontiers in Immunology, 2023 Three-dimensional (3D) genomics is an emerging field of research that investigates the relationship between gene regulatory function and the spatial structure of chromatin.
Yueqi Qiu +13 more
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Structural variation in the 3D genome [PDF]
Nature Reviews Genetics, 2018 Structural and quantitative chromosomal rearrangements, collectively referred to as structural variation (SV), contribute to a large extent to the genetic diversity of the human genome and thus are of high relevance for cancer genetics, rare diseases and evolutionary genetics.
Malte Spielmann +2 more
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Engineering 3D genome organization
Nature Reviews Genetics, 2021 Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function.
Haifeng Wang, Mengting Han, Lei S. Qi
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Nature Methods, 2018 Dip-C, a descendent of the 3C method, reveals 3D genome structures of single diploid human cells.
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3D genome organisation in Drosophila [PDF]
Briefings in Functional Genomics, 2019 AbstractEver since Thomas Hunt Morgan’s discovery of the chromosomal basis of inheritance by using Drosophila melanogaster as a model organism, the fruit fly has remained an essential model system in studies of genome biology, including chromatin organisation.
Moretti, Charlotte +2 more
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