Results 11 to 20 of about 2,629,967 (312)
Mapping the 3D genome architecture
Computational and Structural Biotechnology JournalThe spatial organization of the genome plays a critical role in regulating gene expression, cellular differentiation, and genome stability. This review provides an in-depth examination of the methodologies, computational tools, and frameworks developed ...
Ghazaleh Tavallaee, Elias Orouji
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The Hierarchy of the 3D Genome [PDF]
Molecular Cell, 2013 Mammalian genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Transcriptional control involves the establishment of physical connections among genes and regulatory elements, both along and between chromosomes.
Gibcus, Johan H, Dekker, Job
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3D genomic organization in cancers
Quantitative Biology, 2023 BackgroundThe hierarchical three‐dimensional (3D) architectures of chromatin play an important role in fundamental biological processes, such as cell differentiation, cellular senescence, and transcriptional regulation. Aberrant chromatin 3D structural alterations often present in human diseases and even cancers, but their underlying mechanisms remain ...
Junting Wang 0003 +4 more
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Gene regulation in the 3D genome [PDF]
Human Molecular Genetics, 2018 The spatial organization of the genome is essential for the precise control of gene expression. Recent advances in sequencing and imaging technologies allow us to explore the 3D genome and its relationship to gene regulation at an unprecedented scale.
Yun, Li, Ming, Hu, Yin, Shen
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Engineering 3D genome organization
Nature Reviews Genetics, 2021 Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function.
Haifeng Wang, Mengting Han, Lei S. Qi
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3D genome organization and epigenetic regulation in autoimmune diseases
Frontiers in Immunology, 2023 Three-dimensional (3D) genomics is an emerging field of research that investigates the relationship between gene regulatory function and the spatial structure of chromatin.
Yueqi Qiu +13 more
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Nature Methods, 2018 Dip-C, a descendent of the 3C method, reveals 3D genome structures of single diploid human cells.
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Structural variation in the 3D genome [PDF]
Nature Reviews Genetics, 2018 Structural and quantitative chromosomal rearrangements, collectively referred to as structural variation (SV), contribute to a large extent to the genetic diversity of the human genome and thus are of high relevance for cancer genetics, rare diseases and evolutionary genetics.
Malte Spielmann +2 more
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Nature Methods, 2016 DNA folding shapes gene expression. Emerging techniques promise to reveal the intricacies of this architectural language of chromosomes.
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Enhancer Function in the 3D Genome
Genes, 2023 In this review, we consider various aspects of enhancer functioning in the context of the 3D genome. Particular attention is paid to the mechanisms of enhancer-promoter communication and the significance of the spatial juxtaposition of enhancers and promoters in 3D nuclear space.
Sergey V. Razin +2 more
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