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The Hierarchy of the 3D Genome [PDF]
Molecular Cell, 2013 Mammalian genomes encode genetic information in their linear sequence, but appropriate expression of their genes requires chromosomes to fold into complex three-dimensional structures. Transcriptional control involves the establishment of physical connections among genes and regulatory elements, both along and between chromosomes.
Gibcus, Johan H, Dekker, Job
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3D genomic organization in cancers
Quantitative Biology, 2023 BackgroundThe hierarchical three‐dimensional (3D) architectures of chromatin play an important role in fundamental biological processes, such as cell differentiation, cellular senescence, and transcriptional regulation. Aberrant chromatin 3D structural alterations often present in human diseases and even cancers, but their underlying mechanisms remain ...
Junting Wang 0003 +4 more
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Pan-3D genome analysis reveals structural and functional differentiation of soybean genomes
Genome Biology, 2023 Background High-order chromatin structure plays important roles in gene regulation. However, the diversity of the three-dimensional (3D) genome across plant accessions are seldom reported.
Lingbin Ni +11 more
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Dynamics in the regulatory genome
, 2023 The way in which DNA is uniquely folded in the nucleus into specific conformations enables and/or reflects cell-type specific interactions of active cis-regulatory elements, namely promoters and enhancers, to regulate specific programs of gene expression.
Georgiades, Emily
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Hetero-deformation-induced stress in additively manufactured 316L stainless steel
Materials Research Letters, 2020 Heterogeneous cellular structure combined with bimodal grain structure contributed to the high hetero-deformation-induced (HDI) stress in selective laser melted 316L stainless steel (SLMed 316L SS) and high grain boundary density at molten pool ...
Decheng Kong +5 more
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Three‐dimensional genome structure and function
MedComm, 2023 Linear DNA undergoes a series of compression and folding events, forming various three‐dimensional (3D) structural units in mammalian cells, including chromosomal territory, compartment, topologically associating domain, and chromatin loop.
Hao Liu +7 more
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Engineering 3D genome organization
Nature Reviews Genetics, 2021 Cancers and developmental disorders are associated with alterations in the 3D genome architecture in space and time (the fourth dimension). Mammalian 3D genome organization is complex and dynamic and plays an essential role in regulating gene expression and cellular function.
Haifeng Wang, Mengting Han, Lei S. Qi
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The 3D Genome: From Structure to Function
, 2021 The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and
Ahmed Al-Harrasi +2 more
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Nature Methods, 2018 Dip-C, a descendent of the 3C method, reveals 3D genome structures of single diploid human cells.
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3D genome organisation in Drosophila [PDF]
Briefings in Functional Genomics, 2019 AbstractEver since Thomas Hunt Morgan’s discovery of the chromosomal basis of inheritance by using Drosophila melanogaster as a model organism, the fruit fly has remained an essential model system in studies of genome biology, including chromatin organisation.
Moretti, Charlotte +2 more
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