Results 91 to 100 of about 4,889,916 (279)

Toward understanding the dynamic state of 3D genome

Computational and Structural Biotechnology Journal, 2020
The three-dimensional (3D) genome organization and its role in biological activities have been investigated for over a decade in the field of cell biology.
Soya Shinkai, Shuichi Onami, Ryuichiro Nakato   +2 more
doaj   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

3D HOP release 4.3

, 2020
New release 3D hop 4.
Consortium 3D SHS Team
core  

Defined Matrices Reveal Epithelial‐ and Mesenchymal‐Specific Responses to Stiffness and Adhesion in Human iPSC‐Derived Intestinal Organoids

Advanced Materials, EarlyView.
Defined PEG hydrogels enable human iPSC‐derived intestinal organoid culture without Matrigel. PEG‐ and Matrigel‐cultured organoids both support duodenal‐like epithelial identity, but direct comparison reveals subtle epithelial differentiation‐marker shifts and stronger mesenchymal ECM‐remodeling/integrin programs in PEG.
Alicja Kuziola, Tamara Fawzi, Emma H. Kromann, Marion Leleu, Joanna M. Drelinkiewicz, Dusko Ilic, Cécile A. Dreiss, Joana F. Neves, Eileen Gentleman   +8 more
wiley   +1 more source

3D Genome Architecture Under Stress: A Survey of Ionizing Radiation, Progeria, and Osmotic Stress [PDF]

, 2020
The human nucleus contains 2 meters of DNA which is intricately folded into a three-dimensional (3D) structure. It has become increasingly clear that this 3D structure plays an important role in the expression of genes.
Sanders, Jacob Tyler
core  

A Coaxial Bioprinted Hydrogel With Semipermeable Sheath and Pro‐Chondrogenic Core for Articular Cartilage Repair

Advanced Materials, EarlyView.
A sheath‐core biomimetic hydrogel is engineered with a compartmentalized yet integrated architecture for synergistic multifunctionality. Its stiff, semipermeable sheath mimics the ECM's load‐bearing and protective roles, encapsulating a soft core that provides a pro‐chondrogenic microenvironment similar to the PCM.
Zheyuan Shi, Hua Zhang, Jingying Hu, Guanrong Li, Dianqing Wang, Cuicui Su, Gordon G. Wallace, Qi Gu, Jun Chen, Yingchun Zhu   +9 more
wiley   +1 more source

Conservatoire National de données 3D

, 2020
" Le Conservatoire National des Données 3D SHS est un environnement de sauvegarde sécurisé pour les données 3D, soutenu par Huma-Num. .
Consortium 3D SHS Team
core  

Recent advances in chromosome capture techniques unraveling 3D genome architecture in germ cells, health, and disease

, 2023
In eukaryotes, the genome does not emerge in a specific shape but rather as a hierarchial bundle within the nucleus. This multifaceted genome organization consists of multiresolution cellular structures, such as chromosome territories, compartments ...
Muktiani, Anis, Kustiawan, Limbang, Limbang Kustiawan, Khan, Faheem A., Chunjie Huang, Bambang Waluyo Hadi Eko Prasetiyono, Yousaf, Muhammad R., Azhar Ali, Huang, Chunjie, Putri, Ezi M., Muhammad Rizwan Yousaf, Dimar Sari Wahyuni, Pandupuspitasari, Nuruliarizki S., Windu Negara, Ali, Azhar, Ezi Masdia Putri, Prasetiyono, Bambang W. H. E., Farwa Shakeel, Shakeel, Farwa, Negara, Windu, Wahyuni, Dimar S., Anis Muktiani, Nuruliarizki Shinta Pandupuspitasari, Faheem Ahmed Khan   +23 more
core   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance

Nature Communications, 2019
In breast cancer, the 3D architecture of the genome can impact gene regulation. Here, the authors use tethered chromatin conformation profiling to investigate 3D chromatin structure in models of hormone-induced breast cancer and endocrine resistance ...
Yufan Zhou, Diana L. Gerrard, Junbai Wang, Tian Li, Yini Yang, Andrew J. Fritz, Mahitha Rajendran, Xiaoyong Fu, Gary Stein, Rachel Schiff, Shili Lin, Seth Frietze, Victor X. Jin   +12 more
doaj   +1 more source