Results 171 to 180 of about 110,305 (278)

Deciphering the 3D genome organization across species from Hi-C data. [PDF]

Nucleic Acids Res
Shkolikov A, Galitsyna A, Gelfand MS.
europepmc   +1 more source

Nanoscale nuclear environments, fine-scale 3D genome organization and transcription regulation. [PDF]

Curr Opin Syst Biol, 2022
Li J, Pertsinidis A.
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism. [PDF]

Elife
Das P, San Martin R, Hong T, McCord RP.
europepmc   +1 more source

Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation. [PDF]

Nat Immunol, 2023
Michieletto MF, Tello-Cajiao JJ, Mowel WK, Chandra A, Yoon S, Joannas L, Clark ML, Jimenez MT, Wright JM, Lundgren P, Williams A, Thaiss CA, Vahedi G, Henao-Mejia J.   +13 more
europepmc   +1 more source

MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source

How Chromosome-Nuclear Envelope Attachments Affect 3D Genome Organization

, 2016
The length of eukaryotic chromosomes is many times longer than the nucleus diameter in most cells; thus, their confinement depends on adopting highly folded configurations.
Kinney, Nicholas A.
core  

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Hi-Compass: a depth-aware deep learning framework for predicting cell-type-specific 3D genome organization from single-cell to spatial resolution. [PDF]

Nat Commun
Sun YC, Jiang WJ, Cai KW, Wei NN, Lai FT, Wang HJ, Gao RX, Kuang ZY, Zhou JL, Liu A, Zhu HW, Wang YJ, Xu M, Wu HJ.   +13 more
europepmc   +1 more source

Anopheles mosquitoes reveal new principles of 3D genome organization in insects. [PDF]

Nat Commun, 2022
Lukyanchikova V, Nuriddinov M, Belokopytova P, Taskina A, Liang J, Reijnders MJMF, Ruzzante L, Feron R, Waterhouse RM, Wu Y, Mao C, Tu Z, Sharakhov IV, Fishman V.   +13 more
europepmc   +1 more source