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Decoding the plant genome: From epigenome to 3D organization
Journal of Genetics and Genomics, 2020The linear genome of eukaryotes is partitioned into diverse chromatin states and packaged into a three-dimensional (3D) structure, which has functional implications in DNA replication, DNA repair, and transcriptional regulation. Over the past decades, research on plant functional genomics and epigenomics has made great progress, with thousands of genes
Weizhi Ouyang +4 more
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Spatial Features and Functional Implications of Plant 3D Genome Organization
Annual Review of Plant Biology, 2022The advent of high-throughput sequencing-based methods for chromatin conformation, accessibility, and immunoprecipitation assays has been a turning point in 3D genomics. Altogether, these new tools have been pushing upward the interpretation of pioneer cytogenetic evidence for a higher order in chromatin packing. Here, we review the latest development
Domb, Katherine +3 more
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3D genomics imposes evolution of the domain model of eukaryotic genome organization
Chromosoma, 2016The hypothesis that the genome is composed of a patchwork of structural and functional domains (units) that may be either active or repressed was proposed almost 30 years ago. Here, we examine the evolution of the domain model of eukaryotic genome organization in view of the expansion of genome-scale techniques in the twenty-first century that have ...
Sergey V, Razin, Yegor S, Vassetzky
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3D Genome Organization Influences the Chromosome Translocation Pattern
2018Recent imaging, molecular, and computational modeling studies have greatly enhanced our knowledge of how eukaryotic chromosomes are folded in the nuclear space. This work has begun to reveal how 3D genome structure contributes to various DNA-mediated metabolic activities such as replication, transcription, recombination, and repair.
Rachel Patton, McCord +1 more
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3D genome organization and beyond!
Current Opinion in Structural Biology, 2023Geneviève, Almouzni, Juan M, Vaquerizas
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Shaping Up the Embryo: The Role of Genome 3D Organization
2018The spatial organization of the chromatinized genome inside the cell nucleus impacts genomic function. In transcription, the hierarchical genome structure creates spatial regulatory landscapes, in which modulating elements like enhancers can contact their target genes and activate their expression, as a result of restricting their exploration to a ...
Karina, Jácome-López +1 more
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3D genome organization, genetic variation and disease
Seminars in Cell & Developmental Biology, 2022Justin M, O'Sullivan, Tayaza, Fadason
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Chromothripsis Rearrangements Are Informed by 3D-Genome Organization
2022Natalia Petukhova +4 more
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Phase Separation in Genome Organization Across Evolution
Trends in Cell Biology, 2021Marina Feric, Tom Misteli
exaly
Translating Cancer Genomes and Transcriptomes for Precision Oncology
Ca-A Cancer Journal for Clinicians, 2016Sunita Shankar, Sameek Roychowdhury
exaly