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Shaping Up the Embryo: The Role of Genome 3D Organization
2018The spatial organization of the chromatinized genome inside the cell nucleus impacts genomic function. In transcription, the hierarchical genome structure creates spatial regulatory landscapes, in which modulating elements like enhancers can contact their target genes and activate their expression, as a result of restricting their exploration to a ...
Karina, Jácome-López +1 more
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3D Genome Organization Influences the Chromosome Translocation Pattern
2018Recent imaging, molecular, and computational modeling studies have greatly enhanced our knowledge of how eukaryotic chromosomes are folded in the nuclear space. This work has begun to reveal how 3D genome structure contributes to various DNA-mediated metabolic activities such as replication, transcription, recombination, and repair.
Rachel Patton, McCord +1 more
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3D genome organization, genetic variation and disease
Seminars in Cell & Developmental Biology, 2022Justin M, O'Sullivan, Tayaza, Fadason
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Chromothripsis Rearrangements Are Informed by 3D-Genome Organization
2022Natalia Petukhova +4 more
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3D Genome Organization in Brown Algae
The three-dimensional (3D) organization of the genome plays a crucial role in gene regulation and epigenetic states. In animal genomes, core 3D genome features like topologically associated domains (TADs) and chromatin loops have been extensively characterized, whereas in plants such higher order structures are less pronounced.openaire +4 more sources
Phase separation in genome organization across evolution
Trends in Cell Biology, 2021Marina Feric, Tom Misteli
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Three-dimensional genome organization in immune cell fate and function
Nature Reviews Immunology, 2022Ralph Stadhouders +2 more
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Chromosome-level organization of the regulatory genome in the Drosophila nervous system
Cell, 2023Maria Cristina Gambetta
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Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin
Cell, 2020Seon Shmuel Kinrot +2 more
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Organization and expression of the mammalian mitochondrial genome
Nature Reviews Genetics, 2022Oliver Rackham +2 more
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