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Advanced Science, EarlyView.The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang +9 more
wiley +1 more source
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, EarlyView.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source
Comparative 3D genome organization in apicomplexan parasites [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and has a complex and dynamic relationship with gene expression.
Evelien M Bunnik +2 more
exaly +10 more sources
Understanding 3D genome organization by multidisciplinary methods [PDF]
Nature Reviews Molecular Cell Biology, 2021 Understanding how chromatin is folded in the nucleus is fundamental to understanding its function. Although 3D genome organization has been historically difficult to study owing to a lack of relevant methodologies, major technological breakthroughs in genome-wide mapping of chromatin contacts and advances in imaging technologies in the twenty-first ...
Giacomo Cavalli +2 more
exaly +3 more sources
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Organization and function of the 3D genome
Nature Reviews Genetics, 2016Understanding how chromatin is organized within the nucleus and how this 3D architecture influences gene regulation, cell fate decisions and evolution are major questions in cell biology. Despite spectacular progress in this field, we still know remarkably little about the mechanisms underlying chromatin structure and how it can be established, reset ...
Bonev, B, Cavalli, Giacomo
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An Algorithm for the Analysis of the 3D Spatial Organization of the Genome
2020We present an algorithm, and its MATLAB implementation, based on mathematical methods to detect and localize 3D multicolor DNA FISH spots in fluorescence cell image z-stacks. This algorithm provides a method to measure the relative positioning of spots in the nucleus and inter-spot distances with the aim to enrich our understanding of the 3D spatial ...
Gregoretti Francesco +4 more
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The role of 3D genome organization in development and cell differentiation
Nature Reviews Molecular Cell Biology, 2019In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically packaged inside the nucleus. This complex genome organization includes multiscale structural units of chromosome territories, compartments, topologically associating domains, which are often demarcated by architectural proteins such as CTCF and cohesin, and ...
Hui Zheng, Wei Xie
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Decoding the plant genome: From epigenome to 3D organization
Journal of Genetics and Genomics, 2020The linear genome of eukaryotes is partitioned into diverse chromatin states and packaged into a three-dimensional (3D) structure, which has functional implications in DNA replication, DNA repair, and transcriptional regulation. Over the past decades, research on plant functional genomics and epigenomics has made great progress, with thousands of genes
Weizhi Ouyang +4 more
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