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Spatial Features and Functional Implications of Plant 3D Genome Organization
Annual Review of Plant Biology, 2022The advent of high-throughput sequencing-based methods for chromatin conformation, accessibility, and immunoprecipitation assays has been a turning point in 3D genomics. Altogether, these new tools have been pushing upward the interpretation of pioneer cytogenetic evidence for a higher order in chromatin packing. Here, we review the latest development
Domb, Katherine +3 more
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The 3D organization of the Mammalian Genome
The FASEB Journal, 2016The 3D genome organization plays an essential role in orchestrating the many essential nuclear processes including gene regulation. Great strides have been made recently to characterize the 3D chromatin architecture in mammalian cells, with the development of both technologies for genome‐wide study of chromatin interactions at increasing precision and ...
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3D genomics imposes evolution of the domain model of eukaryotic genome organization
Chromosoma, 2016The hypothesis that the genome is composed of a patchwork of structural and functional domains (units) that may be either active or repressed was proposed almost 30 years ago. Here, we examine the evolution of the domain model of eukaryotic genome organization in view of the expansion of genome-scale techniques in the twenty-first century that have ...
Sergey V, Razin, Yegor S, Vassetzky
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Shaping Up the Embryo: The Role of Genome 3D Organization
2018The spatial organization of the chromatinized genome inside the cell nucleus impacts genomic function. In transcription, the hierarchical genome structure creates spatial regulatory landscapes, in which modulating elements like enhancers can contact their target genes and activate their expression, as a result of restricting their exploration to a ...
Karina, Jácome-López +1 more
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3D Genome Organization Influences the Chromosome Translocation Pattern
2018Recent imaging, molecular, and computational modeling studies have greatly enhanced our knowledge of how eukaryotic chromosomes are folded in the nuclear space. This work has begun to reveal how 3D genome structure contributes to various DNA-mediated metabolic activities such as replication, transcription, recombination, and repair.
Rachel Patton, McCord +1 more
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3D genome organization and beyond!
Current Opinion in Structural Biology, 2023Geneviève, Almouzni, Juan M, Vaquerizas
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3D genome organization, genetic variation and disease
Seminars in Cell & Developmental Biology, 2022Justin M, O'Sullivan, Tayaza, Fadason
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Chromothripsis Rearrangements Are Informed by 3D-Genome Organization
2022Natalia Petukhova +4 more
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Phase separation in genome organization across evolution
Trends in Cell Biology, 2021Marina Feric, Tom Misteli
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Three-dimensional genome organization in immune cell fate and function
Nature Reviews Immunology, 2022Sergi Cuartero +2 more
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