Results 51 to 60 of about 9,574 (212)

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Journal of Pain Research, 2021
Dajung J Kim, Hassan Jassar, Manyoel Lim, Thiago D Nascimento, Alexandre F DaSilva Headache and Orofacial Pain Effort (H.O.P.E.), Biologic and Material Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, 48109 ...
Kim DJ, Jassar H, Lim M, Nascimento TD, DaSilva AF   +4 more
doaj  

A community‐partnered process for construct & measure development: The 3Rs: Reading, Racial equity, & Relationships

American Journal of Community Psychology, EarlyView.
Abstract This paper describes a 3‐year community–partnered research initiative focused on advancing early reading, racial equity, and relationships—collectively known as the 3Rs Initiative. The project brought together researchers and community members committed to ensuring that all adults in the county embody a shared “3Rs mindset” to better support ...
Shannon B. Wanless, Meghan C. Orman, Shallegra Moye, Caitlin F. Spear   +3 more
wiley   +1 more source

Inteins: Localized Distribution, Gene Regulation, and Protein Engineering for Biological Applications

Microorganisms, 2018
Inteins are self-splicing polypeptides with an ability to excise themselves from flanking host protein regions with remarkable precision; in the process, they ligate flanked host protein fragments.
Theetha L. Pavankumar
doaj   +1 more source

Determinants of 3Rs behaviour in plastic usage: A study among Malaysians

Heliyon, 2020
This research was conducted to explore the factors affecting Malaysians’ application of reduce, reuse and recycle (3Rs) concept in plastic usage. This study adopted variables from the Theory of Planned Behaviour (TPB), namely, attitude, subjective norm ...
Loh Chun T'ing, Krishna Moorthy, Chin Yoon Mei, Foo Pik Yin, Wong Zhi Ying, Chin Wei Khong, Gan Zhao Chern, Thong Zin Lin   +7 more
doaj   +1 more source

The 3Rs of Cell Therapy [PDF]

Stem Cells Translational Medicine, 2016
Abstract The 3Rs for a good education are “reading, 'riting, and 'rithmetic.” The basis for good health care solutions for the emergent field of cell therapy in the future will also involve 3Rs: regulation, reimbursement, and realization of value. The business models in this new field of cell therapy will involve these 3Rs.
Caplan, AI, Mason, C, Reeve, B
openaire   +3 more sources

Wireless blood pressure sensor implantation in sheep: A detailed technique

Animal Models and Experimental Medicine, EarlyView.
Twelve adult sheep underwent wireless blood pressure sensor implantation. The procedure lasted an average of 36 min, with mean systolic and diastolic blood pressures of 93 ± 6 and 65 ± 5 mmHg, respectively. This rapid, minimally invasive protocol is a powerful platform for cardiovascular device development.
David Santer, Paul Ecker, Judith Radloff, Katharina Heissl, Smruti Mirchandani, Sabine Leitner, Bruno Mora, Martin Czerny, Roman Gottardi, Michael Moore, Bruno K. Podesser   +10 more
wiley   +1 more source

Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma

Animal Models and Experimental Medicine, EarlyView.
Lung maneuvers of small amplitudes, such as the ones performed in oscillometry, are the current gold standard to probe lung mechanics in animals, but they are insensitive to detect baseline physiological alterations in mouse models of asthma. Herein, lung maneuvers of different amplitudes were compared in two mouse models of asthma.
Magali Boucher, Cyndi Henry, Marie‐Josée Beaulieu, Andrés Rojas‐Ruiz, Ynuk Bossé   +4 more
wiley   +1 more source