Results 41 to 50 of about 775 (125)
Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics [PDF]
, 2015 In a previous work, we have shown that penalized regression approaches can allow many genetic variants to be incorporated into sophisticated pharmacokinetic (PK) models in a way that is both computationally and statistically efficient.
Balding, DJ, Bertrand, J, De Iorio, M
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Scientific Reports, 2021 To investigate pharmacokinetic and pharmacodynamic differences of zolpidem between males and females and their causes, including CYP3A4 activity. A single oral dose of zolpidem (10 mg) was administered to 15 male and 15 female healthy subjects.
Seonghae Yoon +8 more
doaj +1 more source
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity. [PDF]
, 2021 Individualized assessment of cytochrome P450 2D6 (CYP2D6) activity is usually performed through phenotyping following administration of a probe drug to measure the enzyme's activity.
Bararpour, N. +11 more
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, 2010 Multinuclear solid state MAS NMR (1H and 31P), 31P CSA solid state NMR, 2H NMR and x-ray diffraction techniques have been used to compare the structure and properties of DPPC: Andro and DPPC: 4β-hydroxycholesterol with that of the properties known of ...
Trevenen, Alexandra H +1 more
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Association between low body weight and cytochrome P-450 enzyme activity in patients with anorexia nervosa [PDF]
, 2020 Very little is known to which extent severe underweight could affect cytochrome P-450 (CYP) enzyme activity. In this study, 24 patients with anorexia nervosa at two occasions ingested single oral doses of five test drugs known to be metabolized by CYP1A2,
Hegstad, Solfrid +3 more
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CPT: Pharmacometrics & Systems Pharmacology, 2021 Ivosidenib is a potent, targeted, orally active, small‐molecule inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) that has been approved in the United States for the treatment of adults with newly diagnosed acute myeloid leukemia (AML) who are ...
Jayaprakasam Bolleddula +3 more
doaj +1 more source
Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs [PDF]
, 2023 The cytochrome P450 (CYP) enzyme family is the major enzyme system catalyzing the phase I metabolism of xenobiotics, including pharmaceuticals and toxic compounds in the environment.
Alessia Catalano +8 more
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Chromatography of oxysterols [PDF]
, 2018 Oxysterols play important roles in development and diseases, but can be highly challenging to analyze. To ensure satisfactory measurements, oxysterols must typically be separated with chromatography prior to detection.
Dias, Irundika H.k. +2 more
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Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome
Epilepsia, EarlyView.Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan +14 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du +5 more
wiley +1 more source