Results 61 to 70 of about 3,746 (131)

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age‐Related Alterations

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
The uncinate fasciculus (UF), which serves to connect the anterior temporal lobe and the orbitofrontal cortex, is a highly understudied white matter fiber bundle. In this study, we characterized the fatty acid (FA) profile of myelin phospholipids in a fraction‐specific manner, as well as the cholesterol concentrations, in the human postmortem UF.
Kelly Perlman, Chuck T. Chen, Mackenzie E. Smith, John Kim, Gustavo Turecki, Richard P. Bazinet, Naguib Mechawar   +6 more
wiley   +1 more source

DataSheet_1_4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.pdf

, 2020
Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol.
Jaana Rysä (314845), Tuulia Hyötyläinen (139327), Heidi Hautajärvi (8627643), Justiina Ronkainen (8627640), Janne Hukkanen (648692), Jukka Hakkola (298462), Markku J. Savolainen (8397378), Ari Tolonen (1456093), Päivi Känsäkoski (8627646), Tuire Salonurmi (296831), Heba Nabil (8627637), Matej Orešič (43155)   +11 more
core   +1 more source

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol

, 2011
Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs.
Hanna Nylén (18685588)
core  

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS

, 2018
Cholesterol oxidation product 4β‑hydroxycholesterol (4β‑OHC) may possibly be used as an endogenous biomarker of CYP3A enzyme activity and as CYP3A4 is involved in the metabolism of approximately 50% of the drugs in clinical use, the monitoring of CYP3A ...
Hautajärvi, H. (Heidi), Hukkanen, J. (Janne), Tolonen, A. (Ari), Turpeinen, M. (Miia), Mattila, S. (Sampo)   +4 more
core  

Studies on 4b-hydroxycholesterol, a marker of CYP3A activity, and its association with 25-hydroxyvitamin D

, 2015
Cholesterol is a vital compound that can undergo cytochrome P450 (CYP) mediated conversion into steroid hormones, bile acids and oxysterols. CYP enzymes are present in all human tissues and mediate the metabolism of several endogenous and exogenous ...
Hanna Nylén (18685588)
core  

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +1 more source

Oxysterol-mediated modulation of intestinal inflammation: insights into sex differences and GPR183 signaling

Cellular and Molecular Life Sciences
Background and aims Oxysterols, oxidized derivatives of cholesterol, play complex roles in inflammatory processes, but their specific functions in inflammatory bowel diseases remain incompletely understood.
Hafsa Ameraoui, Joan Bestard-Escalas, Martin Roumain, Adam Laghouati, Pauline Bottemanne, Mireille Alhouayek, Giulio G. Muccioli   +6 more
doaj   +1 more source