Results 71 to 80 of about 3,746 (131)

Studies on 4b-hydroxycholesterol, a marker of CYP3A activity, and its association with 25-hydroxyvitamin D [Elektronisk resurs]

, 2015
Cholesterol is a vital compound that can undergo cytochrome P450 (CYP) mediated conversion into steroid hormones, bile acids and oxysterols. CYP enzymes are present in all human tissues and mediate the metabolism of several endogenous and exogenous ...
Nylén, H
core  

Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes

, 2019
Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β-hydroxycholesterol (7β-OHC).
Ilham Badreddine (6838493), Claudio Caccia (87835), Mustapha Cherkaoui-Malki (618942), Mohammad Samadi (3028275), Valerio Leoni (440542), Gérard Lizard (3300573), Anne Vejux (6838502), Thomas Nury (6838490), Boubker Nasser (779666), Amira Zarrouk (6838487), Thibault Moreau (765638), Ahmed Salhedine Masmoudi (6838505), Randa Sghaier (6838484), Nora O’Brien (6838496), John J. Mackrill (6838499)   +14 more
core   +1 more source

Nuclear receptors CAR and PXR as cardiometabolic regulators

Pharmacological Research
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) were initially described as xenobiotic sensors, but an increasing number of studies have linked their activity to other important physiological processes including glucose and lipid
Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä   +3 more
doaj   +1 more source

Pregnancy Increases CYP3A Enzymes Activity as Measured by the 4β-Hydroxycholesterol/Cholesterol Ratio. [PDF]

Int J Mol Sci, 2022
Mlugu EM, Minzi OM, Kamuhabwa AAR, Diczfalusy U, Aklillu E.   +4 more
europepmc   +1 more source

Metabolism of 4 beta -hydroxycholesterol in humans

, 2002
One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4.
Björkhem, Ingemar, Norlin, Maria,, Diczfalusy, Ulf, Andersson, Ulla, Eggertsen, Gösta, Rystedt, Eva, Ellis, Eva, Bodin, Karl, Pikuleva, Irina   +8 more
core   +1 more source

Bobbing of 27-hydroxycholesterol.

, 2018
<p>Movie showing the bobbing of 27-hydroxycholesterol.</p ...
Kulig, Waldemar, Kulig, Waldemar (5268277)   +1 more
core   +1 more source

Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time. [PDF]

Eur J Clin Pharmacol, 2022
Tung NP, Ma JD.
europepmc   +1 more source

Gene Polymorphisms of NLRP3 Associated With Plasma Levels of 4β-Hydroxycholesterol, an Endogenous Marker of CYP3A Activity, in Patients With Asthma [PDF]

Inflammation decreases the activity of cytochrome P450 3A (CYP3A). Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) is responsible for regulating the inflammatory response, and its genetic ...
Hirai, Keita, Kimura, Tomoki, Suzuki, Yuya, Itoh, Kunihiro, Shirai, Toshihiro, Shimoshikiryo, Takayuki   +5 more
core   +1 more source

Modeling and simulation of the endogenous CYP3A induction marker 4β-hydroxycholesterol during enasidenib treatment

Clinical Pharmacology: Advances and Applications, 2019
Yan Li,1 Jamie N Connarn,1 Jian Chen,2 Zeen Tong,2 Maria Palmisano,1 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ, USA; 2Non-Clinical Development, Celgene Corporation, Summit, NJ, USA Background ...
Li Y, Connarn JN, Chen J, Tong Z, Palmisano M, Zhou S   +5 more
doaj  

Response to: "Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time". [PDF]

Eur J Clin Pharmacol, 2022
Kvitne KE, Hole K, Molden E, Robertsen I.   +3 more
europepmc   +1 more source