Results 71 to 80 of about 4,522 (127)

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

DataSheet_1_4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.pdf

, 2020
Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol.
Jaana Rysä (314845), Tuulia Hyötyläinen (139327), Heidi Hautajärvi (8627643), Justiina Ronkainen (8627640), Janne Hukkanen (648692), Jukka Hakkola (298462), Markku J. Savolainen (8397378), Ari Tolonen (1456093), Päivi Känsäkoski (8627646), Tuire Salonurmi (296831), Heba Nabil (8627637), Matej Orešič (43155)   +11 more
core   +1 more source

Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS

, 2018
Cholesterol oxidation product 4β‑hydroxycholesterol (4β‑OHC) may possibly be used as an endogenous biomarker of CYP3A enzyme activity and as CYP3A4 is involved in the metabolism of approximately 50% of the drugs in clinical use, the monitoring of CYP3A ...
Hautajärvi, H. (Heidi), Hukkanen, J. (Janne), Tolonen, A. (Ari), Turpeinen, M. (Miia), Mattila, S. (Sampo)   +4 more
core  

Oxysterol-mediated modulation of intestinal inflammation: insights into sex differences and GPR183 signaling

Cellular and Molecular Life Sciences
Background and aims Oxysterols, oxidized derivatives of cholesterol, play complex roles in inflammatory processes, but their specific functions in inflammatory bowel diseases remain incompletely understood.
Hafsa Ameraoui, Joan Bestard-Escalas, Martin Roumain, Adam Laghouati, Pauline Bottemanne, Mireille Alhouayek, Giulio G. Muccioli   +6 more
doaj   +1 more source

Nuclear receptors CAR and PXR as cardiometabolic regulators

Pharmacological Research
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) were initially described as xenobiotic sensors, but an increasing number of studies have linked their activity to other important physiological processes including glucose and lipid
Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä   +3 more
doaj   +1 more source

Studies on 4b-hydroxycholesterol, a marker of CYP3A activity, and its association with 25-hydroxyvitamin D [Elektronisk resurs]

, 2015
Cholesterol is a vital compound that can undergo cytochrome P450 (CYP) mediated conversion into steroid hormones, bile acids and oxysterols. CYP enzymes are present in all human tissues and mediate the metabolism of several endogenous and exogenous ...
Nylén, H
core  

Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes

, 2019
Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β-hydroxycholesterol (7β-OHC).
Ilham Badreddine (6838493), Claudio Caccia (87835), Mustapha Cherkaoui-Malki (618942), Mohammad Samadi (3028275), Valerio Leoni (440542), Gérard Lizard (3300573), Anne Vejux (6838502), Thomas Nury (6838490), Boubker Nasser (779666), Amira Zarrouk (6838487), Thibault Moreau (765638), Ahmed Salhedine Masmoudi (6838505), Randa Sghaier (6838484), Nora O’Brien (6838496), John J. Mackrill (6838499)   +14 more
core   +1 more source

Pregnancy Increases CYP3A Enzymes Activity as Measured by the 4β-Hydroxycholesterol/Cholesterol Ratio. [PDF]

Int J Mol Sci, 2022
Mlugu EM, Minzi OM, Kamuhabwa AAR, Diczfalusy U, Aklillu E.   +4 more
europepmc   +1 more source

Metabolism of 4 beta -hydroxycholesterol in humans

, 2002
One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4.
Björkhem, Ingemar, Norlin, Maria,, Diczfalusy, Ulf, Andersson, Ulla, Eggertsen, Gösta, Rystedt, Eva, Ellis, Eva, Bodin, Karl, Pikuleva, Irina   +8 more
core   +1 more source

Modeling and simulation of the endogenous CYP3A induction marker 4β-hydroxycholesterol during enasidenib treatment

Clinical Pharmacology: Advances and Applications, 2019
Yan Li,1 Jamie N Connarn,1 Jian Chen,2 Zeen Tong,2 Maria Palmisano,1 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ, USA; 2Non-Clinical Development, Celgene Corporation, Summit, NJ, USA Background ...
Li Y, Connarn JN, Chen J, Tong Z, Palmisano M, Zhou S   +5 more
doaj