4-Aminopyridine treatment for nerve injury resulting from radical retro-pubic prostatectomy: a single-center double-blind, randomized, placebo-controlled study [PDF]
TrialsBackground Prostate cancer (PCa) is the most common non-cutaneous malignancy in men and leads to the second most common cause of cancer related mortality in men. Early detection of PCa allows for a potentially curative intervention.
Ahmed Ghazi +4 more
doaj +4 more sources
KCNA1 gain‐of‐function epileptic encephalopathy treated with 4‐aminopyridine [PDF]
Annals of Clinical and Translational Neurology, 2023 Precision medicine for Mendelian epilepsy is rapidly developing. We describe an early infant with severely pharmacoresistant multifocal epilepsy. Exome sequencing revealed the de novo variant p.(Leu296Phe) in the gene KCNA1, encoding the voltage‐gated K+
Peter Müller +10 more
doaj +2 more sources
4-aminopyridine – the new old drug for the treatment of neurodegenerative diseases [PDF]
Pharmacia, 2019 In this review are described the preclinical and clinical pharmacological data as well as new therapeutic indications for the use of 4-aminopyridine.
Ivanka Kostadinova, Nikolai Danchev
doaj +4 more sources
Neuroprotective Properties of 4-Aminopyridine. [PDF]
Neurol Neuroimmunol Neuroinflamm, 2021 As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used as symptomatic therapy in several neurologic disorders. The improvement of visual function and motor skills and relieve of fatigue in patients with MS have been attributed to 4-AP.
Dietrich M, Hartung HP, Albrecht P.
europepmc +4 more sources
Hydroxyapatite and Silicon-Modified Hydroxyapatite as Drug Carriers for 4-Aminopyridine [PDF]
Crystals, 2021 Adsorption and desorption properties of nano-hydroxyapatite (HAP) and silicon-modified hydroxyapatite (Si–HAP) were investigated with 4-aminopyridine (fampridine-4AP). The novelty of this research is the investigation of the suitability of the previously
Laura Marincaș +7 more
doaj +2 more sources
Two new zinc(II) acetates with 3– and 4–aminopyridine: syntheses and structural properties [PDF]
Acta Chimica Slovenica, 2015 The synthesis and characterization of two new zinc(II) coordination compounds with 3– and 4–aminopyridine are reported. They were obtained after dissolving Zn(CH3COO)2·2H2O in different solutions of 3– and 4–aminopyridine. The products were characterized
Brina Dojer +3 more
doaj +2 more sources
Optical triggered seizures using a caged 4-Aminopyridine [PDF]
Frontiers in Neuroscience, 2015 Animal models of epilepsy are critical not only for understanding the fundamental mechanism of epilepsy but also for testing the efficacy of new antiepileptic drugs and novel therapeutic interventions.
Mingrui eZhao +7 more
doaj +4 more sources
Responsiveness to progesterone and potassium channel blockers 4-aminopyridine, tetraethylammonium and free Ca(2+) contentration in spermatozoa of patients with oligozoospermia/leucocytospermia [PDF]
The Ukrainian Biochemical Journal, 2018 The present study was undertaken to evaluate [Ca2+]i signals that occur in human sperm cells exposed in vitro to three diverse compounds; progesterone, 4-aminopyridine (a highly effective inducer of hyperactivation in human sperm) and tetraethylammonium.
R. V. Fafula +4 more
doaj +2 more sources
Functional improvement in individuals with chronic spinal cord injury treated with 4-aminopyridine: A systematic review [PDF]
Frontiers in Neurology, 2022 Study designSystematic review.ObjectiveTo provide current evidence on the efficacy of 4-aminopyridine (4-AP) to bring about functional improvement in individuals with chronic traumatic spinal cord injury (SCI).MethodsThe Medline (PubMed), Web of Science ...
Martin Paredes-Cruz +6 more
doaj +2 more sources
Dynamic walking features and improved walking performance in multiple sclerosis patients treated with fampridine (4-aminopyridine) [PDF]
, 2015 Background: Impaired walking capacity is a frequent confinement in Multiple Sclerosis (MS). Patients are affected by limitations in coordination, walking speed and the distance they may cover.
Philipp M. Keune +7 more
openalex +5 more sources