KCNA1 gain‐of‐function epileptic encephalopathy treated with 4‐aminopyridine [PDF]
Annals of Clinical and Translational Neurology, 2023 Precision medicine for Mendelian epilepsy is rapidly developing. We describe an early infant with severely pharmacoresistant multifocal epilepsy. Exome sequencing revealed the de novo variant p.(Leu296Phe) in the gene KCNA1, encoding the voltage‐gated K+
Peter Müller +10 more
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Neuroprotective Properties of 4-Aminopyridine. [PDF]
Neurol Neuroimmunol Neuroinflamm, 2021 As an antagonist of voltage-gated potassium (Kv) channels, 4-aminopyridine (4-AP) is used as symptomatic therapy in several neurologic disorders. The improvement of visual function and motor skills and relieve of fatigue in patients with MS have been attributed to 4-AP.
Dietrich M, Hartung HP, Albrecht P.
europepmc +4 more sources
Two new zinc(II) acetates with 3– and 4–aminopyridine: syntheses and structural properties [PDF]
Acta Chimica Slovenica, 2015 The synthesis and characterization of two new zinc(II) coordination compounds with 3– and 4–aminopyridine are reported. They were obtained after dissolving Zn(CH3COO)2·2H2O in different solutions of 3– and 4–aminopyridine. The products were characterized
Brina Dojer +3 more
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Optical triggered seizures using a caged 4-Aminopyridine [PDF]
Frontiers in Neuroscience, 2015 Animal models of epilepsy are critical not only for understanding the fundamental mechanism of epilepsy but also for testing the efficacy of new antiepileptic drugs and novel therapeutic interventions.
Mingrui eZhao +7 more
doaj +4 more sources
The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs [PDF]
Frontiers in Neuroscience, 2019 Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary.
Hanno Heuzeroth +4 more
doaj +3 more sources
Functional improvement in individuals with chronic spinal cord injury treated with 4-aminopyridine: A systematic review [PDF]
Frontiers in Neurology, 2022 Study designSystematic review.ObjectiveTo provide current evidence on the efficacy of 4-aminopyridine (4-AP) to bring about functional improvement in individuals with chronic traumatic spinal cord injury (SCI).MethodsThe Medline (PubMed), Web of Science ...
Martin Paredes-Cruz +6 more
doaj +2 more sources
Sleep Deprivation‐Induced Anxiety Alleviated by Oral Administration of 4‐Aminopyridine in Male Mice [PDF]
Brain and BehaviorPurpose Insufficient sleep and insomnia are common issues associated with modern lifestyles that often contribute to the development of mental health disorders.
Ehsan Hosseini
doaj +2 more sources
Mapping the secondary response to traumatic brain injury using spatial transcriptomics shows acute 4-aminopyridine treatment mitigates axonal and molecular pathology [PDF]
Acta Neuropathologica CommunicationsDamage to long myelinated axons of white matter tracts is a hallmark pathology resulting from traumatic brain injury (TBI) forces and secondary injury processes.
Genevieve M. Sullivan +8 more
doaj +2 more sources
Phase IIB Randomized Trial on the Use of 4-Aminopyridine in Guillain-Barré Syndrome [PDF]
Archives of Rehabilitation Research and Clinical Translation, 2021 Objective: To determine the safety and efficacy of orally delivered 4-aminopyridine (4-AP) in persons with Guillain-Barré Syndrome (GBS) >6 months from initial diagnosis. Design: A randomized, double-blind, placebo-controlled, crossover study.
Jay M. Meythaler, JD, MD +2 more
doaj +2 more sources
GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohortResearch in context [PDF]
EBioMedicineSummary: Background: GAA-FGF14 disease/spinocerebellar ataxia 27B is a recently described neurodegenerative disease caused by (GAA)≥250 expansions in the fibroblast growth factor 14 (FGF14) gene, but its phenotypic spectrum, pathogenic threshold, and ...
David Pellerin +16 more
doaj +2 more sources