Results 31 to 40 of about 21,834 (203)
Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium [PDF]
, 2000 During atrial fibrillation, ventricular rate is determined by atrioventricular nodal (AVN) conduction, which in part is dependent upon the refractoriness of single AVN cells.
Andrew C. Rankin +48 more
core +1 more source
Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]
, 2003 <b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A. +4 more
core +1 more source
HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report
Case Reports in Neurology, 2017 Apart from infectious causes and cerebellar dysfunction associated with acquired immune deficiency syndrome dementia or HIV-associated neurocognitive disorder, cerebellar dysfunction in HIV-positive individuals has been ascribed to granule cell ...
Carolin Hoyer +4 more
doaj +1 more source
Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways
Angewandte Chemie, EarlyView.A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim +3 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2009 Highly potent and selective inhibitors of neuronal nitric oxide synthase (nNOS) possessing a 2-aminopyridine group were recently designed and synthesized in our laboratory and were shown to have significant in vivo efficacy.
Graham R. Lawton +4 more
doaj +1 more source
Physiological sharp wave-ripples and interictal events in vitro: What’s the difference? [PDF]
, 2014 Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features.
Freund, Tamás +7 more
core +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2020 In the crystals of the title compound, C5H7N2+·CNS−·C5H6N2, the components are linked by three N—H...N and two N—H...S hydrogen bonds, resulting in two interpenetrating three-dimensional networks.
M. Renugadevi +3 more
doaj +1 more source
Propagation velocity of epileptiform activity in the hippocampus [PDF]
, 1989 The propagation of epileptiform burst activity was investigated in the CA1 area of the in-vitro hippocampal slice preparation of the guinea pig. This activity was provoked by 0.1 mM 4-aminopyridine in the bathing medium and was recorded in the pyramidal ...
Holsheimer, J., Lopes da Silva, F.H.
core +3 more sources
Spatiotemporal Correlation of Epileptiform Activity and Gene Expression in vitro
Frontiers in Molecular Neuroscience, 2021 Epileptiform activity alters gene expression in the central nervous system, a phenomenon that has been studied extensively in animal models. Here, we asked whether also in vitro models of seizures are in principle suitable to investigate changes in gene ...
Sophie Schlabitz +9 more
doaj +1 more source
Acta Crystallographica Section E, 2012 In the title complex, [Cu(C13H11N2O)Cl(C6H8N2)], the CuII atom adopts a distorted tetrahedral geometry being coordinated by the phenolic O atom and the azomethine N atom of the Schiff base ligand N-salicylidene 2-aminopyridine, and by the 2-aminopyridine
Bussa Bhagyaraju +2 more
doaj +1 more source