Effects of 4- Aminopyridine on Inflammatory Reactions in Experimental Models [PDF]
پیاورد سلامت, 2009 Background And Aim : Nowadays, many inflammatory diseases such as rheumatoid arthritis (RA) and Multiple sclerosis (MS) and many other autoimmune inflammatory diseases has involved the people of different communities and cure for them so far has not been
SA Mirshafyei +6 more
doaj +2 more sources
Twisted Intramolecular Charge Transfer in Protonated Amino Pyridine [PDF]
, 2016 International audienceThe excited state properties of protonated ortho (2-), meta (3-) and para (4-) aminopyridine molecules have been investigated through UV photo fragmentation spectroscopy and excited state couple cluster CC2 calculations.
Broquier, Michel +5 more
core +4 more sources
Abnormal Action Potentials Associated with the Shaker Complex Locus of Drosophila [PDF]
, 1981 Intracellular recordings of action potentials were made from the cervical giant axon in Shaker (Sh) mutants and normal Drosophila. The mutants showed abnormally long delays in repolarization.
Ferrus, Alberto +2 more
core +1 more source
Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium [PDF]
, 2000 During atrial fibrillation, ventricular rate is determined by atrioventricular nodal (AVN) conduction, which in part is dependent upon the refractoriness of single AVN cells.
Andrew C. Rankin +48 more
core +1 more source
4-Aminopyridine inhibits the neuromuscular effects of nitric oxide and 8-Br-cGMP
Brazilian Journal of Medical and Biological Research, 2003 The effects induced by nitric oxide (NO) in different tissues depend on direct and/or indirect interactions with K+ channels. The indirect interaction of NO is produced by activation of guanylyl cyclase which increases the intracellular cGMP.
R.N. Queiroz +2 more
doaj +1 more source
The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons [PDF]
, 1994 1. Electrotonic responses to 150 ms current pulses were recorded from isolated rat dorsal roots incubated for at least 3 h with either normal (5 mM) or high (25 mM) D-glucose solutions, and with either normal (25 mM) or low (5 mM) bicarbonate ...
Bostock, Hugh +2 more
core +2 more sources
Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]
, 2003 <b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A. +4 more
core +1 more source
Angewandte Chemie, EarlyView.This work reports, for the first time, aggregation‐ or crystallization‐induced emission in boron‐substituted carboranes, which was driven by photoinduced charge‐transfer from fluorophore attached via boron vertices. The emission properties can be tuned by varying the substituents, expanding design strategies for luminescent materials.
Balázs Szathmári +9 more
wiley +2 more sources
Spatiotemporal Correlation of Epileptiform Activity and Gene Expression in vitro
Frontiers in Molecular Neuroscience, 2021 Epileptiform activity alters gene expression in the central nervous system, a phenomenon that has been studied extensively in animal models. Here, we asked whether also in vitro models of seizures are in principle suitable to investigate changes in gene ...
Sophie Schlabitz +9 more
doaj +1 more source
HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report
Case Reports in Neurology, 2017 Apart from infectious causes and cerebellar dysfunction associated with acquired immune deficiency syndrome dementia or HIV-associated neurocognitive disorder, cerebellar dysfunction in HIV-positive individuals has been ascribed to granule cell ...
Carolin Hoyer +4 more
doaj +1 more source