Results 151 to 160 of about 26,058,575 (297)

Corporate R&D Investments Following Competitors’ Disclosures: Evidence from the Drug Development Process [PDF]

, 2020
This dissertation studies the role of peer disclosures in shaping corporate R&D investments. Using the online registration of clinical trials in the drug development process, I find that a firm’s R&D investments are deterred by disclosures of clinical ...
Zhang, Yue
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Correction to: Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer. [PDF]

Eur J Nucl Med Mol Imaging, 2021
Chitalia R, Viswanath V, Pantel AR, Peterson LM, Gastounioti A, Cohen EA, Muzi M, Karp J, Mankoff DA, Kontos D.   +9 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Pandora: 4-D White Matter Bundle Population-Based Atlases Derived from Diffusion MRI Fiber Tractography. [PDF]

Neuroinformatics, 2021
Hansen CB, Yang Q, Lyu I, Rheault F, Kerley C, Chandio BQ, Fadnavis S, Williams O, Shafer AT, Resnick SM, Zald DH, Cutting LE, Taylor WD, Boyd B, Garyfallidis E, Anderson AW, Descoteaux M, Landman BA, Schilling KG.   +18 more
europepmc   +1 more source

Minuta 4

, 1986
ALADI. Comité de Coordinación y Negociaciones.
ALADI. Comité de Coordinación y Negociaciones. Subcomité 4: Sistema de Apoyo a los Países de Menor Desarrollo Económico Relativo
core  

New [(D-terpyridine)-Ru-(D or A-terpyridine)][4-EtPhCO2](2) complexes (D = electron donor group; A = electron acceptor group) as active second-order non linear optical chromophores

, 2012
The dipolar and octupolar contributions of the second order nonlinear optical properties of [(4′-(C6H4-p-D)-2,2′:6′,2′′-terpyridine)-Ru-(4′-(C6H4-p-A)-2,2′:6′,2′′-terpyridine)]Y2 heteroleptic complexes (D and A are donor and acceptor groups, respectively)
A. Colombo, S. Quici, J. Zyss, S. Fantacci, N. Tancrez, D. Roberto, F. De Angelis, M. Cavazzini, I. Ledoux Rak, D. Locatelli, F. Tessore, R. Ugo   +11 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source