Results 161 to 170 of about 32,447,375 (296)

Pandora: 4-D White Matter Bundle Population-Based Atlases Derived from Diffusion MRI Fiber Tractography. [PDF]

Neuroinformatics, 2021
Hansen CB, Yang Q, Lyu I, Rheault F, Kerley C, Chandio BQ, Fadnavis S, Williams O, Shafer AT, Resnick SM, Zald DH, Cutting LE, Taylor WD, Boyd B, Garyfallidis E, Anderson AW, Descoteaux M, Landman BA, Schilling KG.   +18 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Ages of D/d,n/He sup 3 and T/d,n/He sup 4 neutrons in water and tungsten-water mixtures [PDF]

, 1968
Ages for D-D and D-T neutrons in water and tungsten-water ...
Shook, D. F., Bogart, D., Alexander, R. L.   +2 more
core  

Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer. [PDF]

Eur J Nucl Med Mol Imaging, 2021
Chitalia R, Viswanath V, Pantel AR, Peterson LM, Gastounioti A, Cohen EA, Muzi M, Karp J, Mankoff DA, Kontos D.   +9 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Pilot study using virtual 4-D tracking electromagnetic navigation bronchoscopy in the diagnosis of pulmonary nodules: a single center prospective study. [PDF]

J Thorac Dis, 2021
Ishiwata T, Ujiie H, Gregor A, Inage T, Motooka Y, Kinoshita T, Aragaki M, Chen Z, Effat A, Bernards N, Yasufuku K.   +10 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

THE EFFECT OF A 12-MONTH WEIGHT LOSS INTERVENTION ON VITAMIN D STATUS IN SEVERELY OBESE CAUCASIANS AND AFRICAN AMERICAN ADULTS [PDF]

, 2012
Vitamin D deficiency is a potential risk factor for several chronic conditions, including cardiovascular disease, diabetes and immune disorders. Several studies have found an association between Vitamin D deficiency and obesity, yet it is unclear whether
Rompolski, Krista
core