Results 131 to 140 of about 5,843 (268)

Establishing the Thermodynamic Cards of Dipine Models’ Oxidative Metabolism on 21 Potential Elementary Steps

Molecules
Dipines are a type of important antihypertensive drug as L-calcium channel blockers, whose core skeleton is the 1,4-dihydropyridine structure. Since the dihydropyridine ring is a key structural factor for biological activity, the thermodynamics of the ...
Guang-Bin Shen, Shun-Hang Gao, Yan-Wei Jia, Xiao-Qing Zhu, Bao-Chen Qian   +4 more
doaj   +1 more source

A general method for the synthesis of bridged indole alkaloids [PDF]

, 2020
: The nucleophilic addition of indoleacetic ester enolates to pyridinium salts, followed by acid-promoted cyclization of the intermediate 1 ,4-dihydropyridines, leads to tetracyclic substructures of C-mavacurine, Strychnos, and akuammiline alkaloids ...
Joan Bosch, M.-Lluisa Bennasar, Mercedes Amat   +2 more
core  

Characterization of 4-Oxo-1,4-Dihydropyridine Compound with Ester Moiety Using DFT Calculations

, 2023
Sevgi Kansız, Okan Şimşek
openalex   +2 more sources

Obtenção de sais de piridínio e piridinas através da oxidação de di-hidropiridinas de Hantzsch [PDF]

, 2015
Orientador : Prof. Dr. Alan Guilherme GonçalvesCo-orientador : Prof. Dr. Diogo Ricardo Bazan DucattiCo-orientadora : Profª. Drª. Sandra Mara Woranovicz BarreiraDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa ...
Guanaes, Lais Danciguer, 1989-
core   +1 more source

The anti-Alzheimer potential of new spirooxindole derivatives containing 1,4-dihydropyridines as a targeted cholinesterase inhibitor

Results in Chemistry
In this study, a series of new spirooxindole derivatives containing 1,4-dihydropyridines compounds were designed, synthesized and their cholinesterase inhibitory activities were evaluated.
Hormoz Pourtaher, Mohammad Reza Mohammadizadeh, Arian Aliabadi, Aida Iraji   +3 more
doaj   +1 more source

2-Azabicyclo[3.2.0]heptane-3,4-diones (4). Thermal Rearrangement of 3-Ethoxy-2-azabicyclo[3.2.0]hept-2-en-4-ones Leadng to 2-Ethoxy-3,4-dihydropyridines

, 1981
Takehiro Sano, Yoshie Horiguchi, Yoshisuke Tsuda   +2 more
openalex   +1 more source

Lercanidipine’s Antioxidative Effect Prevents Noise-Induced Hearing Loss

Antioxidants
Noise-induced hearing loss (NIHL) is a prevalent form of adult hearing impairment, characterized by oxidative damage to auditory sensory hair cells. Although certain dihydropyridines, the L-type calcium channel blockers, exhibit protective properties ...
Zhaoqi Guo, E Tian, Sen Chen, Jun Wang, Jingyu Chen, Weijia Kong, Debbie C. Crans, Yisheng Lu, Sulin Zhang   +8 more
doaj   +1 more source

Melamine trisulfonic acid as an efficient catalyst for the synthesis of 2,6-dimethyl-4-substituted-1,4-dihydropyridine-3,5-diethyl/dimethylcarboxylate derivatives via Hantzsch reaction in solvent free condition

, 2013
S. Sheik Mansoor, K. Aswin, K. Logaiya, S.P.N. Sudhan   +3 more
openalex   +1 more source

Synthesis and Characterisation of 1,1′-{[3,5-Bis(dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) Dibromide [PDF]

, 2021
Mārtiņš Ruciņš, Kārlis Pajuste, Aiva Plotniece, Nadiia V. Pikun, R. V. Rodik, Sergiy Vyshnevskiy, Arkadij Sobolev   +6 more
openalex   +1 more source

Synthesis and Evaluation of 1,4-Dihydropyridine-Based Urea Derivatives as Polyphenol Oxidase Inhibitors

Türkiye Tarımsal Araştırmalar Dergisi
This study investigated the potential inhibitory effects of nine novel synthesized urea-substituted 1,4-dihydropyridine derivatives (DT-DEN-1-9) on polyphenol oxidase (PPO) activity.
Mustafa Oğuzhan Kaya, Tuna Demirci, Halil İbrahim Taş, Şeyda Karayağız, Ahmad Badreddin Musatat, Yeşim Kaya, Mine Nazan Kerimak Öner, Oğuzhan Özdemir, Mustafa Arslan   +8 more
doaj   +1 more source