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Synthese et reaction de diacyl-1,4 alkyl-4 dihydropyridines
Tetrahedron, 1973Resume L'action du zinc et des anhydrides acetique, propionique et butyrique sur des pyridines substituees en C-4 donne des diacyl-1,4 alkyl-4 dihydropyridines, qui peuvent egalement etre obtenues par reaction radicalaire. L'acetyl-1 methylene-4 methyl-5 dihydro-4,5 azepine 24 a ete preparee par solvolyse du tosylate 23 , derivant de la diacetyl-1,
P.M. Atlani, J.F. Biellmann, J. Moron
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ChemInform Abstract: SYNTHESIS OF 2,3‐DIHYDROBENZOFURAN‐3‐SPIRO‐4′‐DIHYDROPYRIDINES
Chemischer Informationsdienst, 1982AbstractBei der Kondensation von Salicylaldehydmethylether (I) mit 2‐Acetyl‐furan (II) erhält man unter alkalischen Bedingungen das Diketon (III), das durch weitere Kondensation mit Hydroxylamin, anschließende Permanganatoxidation und Thermolyse über das Pyridin (IVa) und die Dicarbonsäure (IVb) zum Decarboxylierungsprodukt (IVc) führt.
D. D. WELLER, G. R. LUELLEN
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Pflügers Archiv - European Journal of Physiology, 2003
Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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Although often used as a Ca(2+) channel blocker, Mn(2+), in fact, permeates through Ca(2+) channels. Under Na(+)-free conditions, depolarizing pulses evoked slowly-decaying Mn(2+) currents ( I(Mn)). Maximal I(Mn) densities in the presence of 5 and 20 mM Mn(2+) were 0.42+/-0.12 pA/pF (mean+/-SEM, n=17) and 1.23+/-0.10 pA/pF ( n=40), respectively.
Haruko, Masumiya +3 more
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Synthesis of 1, 4-Dihydropyridines using Different Nanocatalyst Systems
Research Journal of Chemistry and Environment1, 4-dihydropyridine (1, 4-DHP) is an important class of heterocyclic scaffold which possesses a wide variety of applications in biological and pharmacological field. In this review, we discuss the synthesis of 1, 4-dihydropyridine by using various nanocatalytic systems since 2010. Nanocatalyst provided efficient and green approach for the synthesis of
Deepak Babasaheb Phasage +2 more
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Analysis of several 1, 4-dihydropyridine drugs ba enantioselective liquid chromatography
2005The chiral resolution of racemic drugs into their enantiomers is of great importance, because the two enantiomers often exhibit different pharmacological activity. This work deals with a group of very popular biologically active 1, 4-dihydropyridine drugs.
Litvić, Mladen, Vinković, Vladimir
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Synthesis of Some New Unsymmetrically Substituted 1,4-Dihydropyridines
Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences, 2006 A series of some new 3,5-unsymmetrically substituted 1,4-dihydropyridines have been synthesized, which have ethoxycarbonyl and acetyl groups on 3-and 5-positions, respectively. A three-step procedure has been examined to increase the yield of the desired
Hamid Reza Memarian +1 more
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Synthesis of 3-cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thionks
Chemistry of Heterocyclic Compounds, 19833-Cyano-4, 6-diaryl-3, 4-dihydropyridine-2-thiones have been synthesized for the first time by the condensation of arylideneacetophenones or 1-piperidino-1-phenyl-2-benzoylethane with cyanothioacetamide and the 1, 1-dicyano-2-aryl-3-benzoylpropane with hydrogen sulfide in the presence of bases. It has been established by PMR spectroscopy that 3-cyano-3,
A. A. Krauze +5 more
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2005
In this study we wish to report that t-butyl hydroperoxide is very efficient oxidant in the presence of iron(III)(phthalocyanine)Cl as catalyst for aromatization of 1, 4-DHPs (I), Scheme 1. These reactions are very clean and completed within ca. 30 minutes depending on substituents attached at phenyl ring.
Vinković, Vladimir +2 more
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In this study we wish to report that t-butyl hydroperoxide is very efficient oxidant in the presence of iron(III)(phthalocyanine)Cl as catalyst for aromatization of 1, 4-DHPs (I), Scheme 1. These reactions are very clean and completed within ca. 30 minutes depending on substituents attached at phenyl ring.
Vinković, Vladimir +2 more
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Rotational Barriers of 4‐Aryl‐1, 4‐dihydropyridines (Ca Antagonists)
Angewandte Chemie International Edition in English, 1984Siegfried Goldmann, Walter Geiger
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Synthesis, properties, and cardiovascular activity of substituted 4-dihydropyridine-2(3H)-thiones
Pharmaceutical Chemistry Journal, 1988A. A. Krauze +3 more
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