Results 121 to 130 of about 9,299,425 (160)

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity. [PDF]

Drug Dev Res
Koçak Aslan E, Lam K, Huang S, Coşkun GP, Karagüzel A, Denzinger K, Birgül K, Ülgen M, Nafie JW, Şahin O, Armstrong DW, Zamponi GW, Wolber G, Gündüz MG.   +13 more
europepmc   +1 more source

Modular assembly of chiral amino acid derivatives and peptides from commonly available feedstocks. [PDF]

Nat Commun
Ding WW, He ZY, Wang WY, Han ZY, Gong LZ.   +4 more
europepmc   +1 more source

Asymmetric Rh-Catalyzed Synthesis of Dihydronicotinamides. [PDF]

J Org Chem
Zerangnasrabad S, Karimov RR.
europepmc   +1 more source

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Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

Mini-Reviews in Medicinal Chemistry, 2021
The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover,
Shubham, Khot, Pratibha B, Auti, Samrat A, Khedkar   +2 more
openaire   +3 more sources

Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor®

Molecules, 2020
New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor®. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen ...
Nadiia V Pikun, Arkadij Sobolev, Aiva Plotniece   +2 more
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N‐alkylation of 1, 4‐dihydropyridine derivatives

Bulletin des Sociétés Chimiques Belges, 1973
AbstractA series of 1‐alkyl‐2, 6‐dimethyl‐3, 5‐diethoxycarbonyl‐4‐aryl‐1, 4‐dihydropyridines have been synthesised by the reaction of the corresponding 1, 4‐dihydro‐pyridines with consecutively sodium hydride and alkyl halides.
R. A. Dommisse, F. C. Alderweireldt
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1, 4‐Dihydropyridine mit Etacrynsäure‐Partialstruktur

Archiv der Pharmazie, 1992
AbstractAusgehend von dem Acetophenon 3 werden über die Nitrobenzyliden‐Verbindungen 4 und 5 die 1,4‐Dihydropyridine (DHP) 6 und 7 mit einem Dichlorphenoxyessigsäure‐Substituenten hergestellt. Die DHP werden zu den Pyridinen 8 und 9 oxidiert. Bei der Bestrahlung des DHP 6a entsteht die cyclische Hydroxamsäure 10.
Klaus Görlitzer, Wolfgang Düwel
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Synthesis of 2,3-dihydrobenzofuran-3-spiro-4′-dihydropyridines

Tetrahedron Letters, 1981
Abstract 2,3-Dihydrobenzofuran-3-spiro-4′-dihydropyridines are readily available via intramolecular addition of enolates to pyridinium ions.
Dwight D. Weller, Glenn R. Luellen
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Recent Approaches to Chiral 1,4-Dihydropyridines and their Fused Analogues

Catalysts, 2020
The purpose of this review is to highlight recent developments in the synthesis of chiral 1,4-dihydropyridines and their fused analogues. 1,4-Dihydropyridines are among the most active calcium antagonists that are used for the treatment of hypertension ...
Martins Rucins, Aiva Plotniece, Eiva Bernotiene   +2 more
exaly   +2 more sources

1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

Mini-Reviews in Medicinal Chemistry, 2014
The 1,4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel modulating agents and have experienced widespread use in the treatment of cardiovascular disease which include antihypertensive, antianginal, vasodilator and cardiac ...
Samrat A, Khedkar, Pratibha B, Auti
openaire   +3 more sources