Results 91 to 100 of about 12,853,470 (222)

Synthesis, Characterization and Effect of bis-1,3,4Oxadiazole Containing Glycine Moiety on the Activity of Some Transferase Enzymes.

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
  We described herein the synthesis of novel bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4methoxybenzamide was fully characterized by elemental analysis, FT-IR ...
I. H. R. Tomi, A. H. J. Al-Qaisi, Z. H. J. Al-Qaisi   +2 more
doaj  

5-[1-(3,4-Dichlorophenoxy)ethyl]-1,3,4-oxadiazole-2(3H)-thione hemihydrate

Acta Crystallographica Section E, 2009
In the title compound, C10H8Cl2N2O2S·0.5H2O, the atoms in the oxadiazole ring are essentially coplanar (r.m.s. deviation 0.010 Å).
Tashfeen Akhtar, M. Khawar Rauf, Shahid Hameed, Xiaoming Lu   +3 more
doaj   +1 more source

Synthesis of Mono-Substituted and Simmetrically 2, 5-Disubstituted 1, 3, 4-Oxadiazoles

Chemistry Journal of Moldova, 2012
This article is an extended abstract of a communication presented at the Conference Ecological Chemistry 2012.
Z. Ribcovskaia, F. Macaev
openaire   +2 more sources

Síntese de cristais líquidos funcionalizados contendo o heterociclo 1,3,4-oxadiazol [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.Neste trabalho são descritas a síntese, a caracterização e os estudos das propriedades ópticas,
Westphal, Eduard
core  

Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β³- and α-Amino Acids from Fmoc-Protected Aspartic Acid

, 2016
Various 3-substituted chiral 1,2,4-oxadiazole-containing Fmoc-β3- and -α-amino acids were synthesized from Fmoc-(l or d)-Asp(OtBu)-OH and Fmoc-l-Asp-OtBu, respectively, in three steps (i.e., condensation of an aspartyl derivative with differentially ...
Jean Martinez (150107), Pierre Fulcrand (2498626), Jean-François Hernandez (2701363), Abdallah Hamzé, (2701360)   +3 more
core   +3 more sources

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source

SYNTHESIS AND EVALUATION OF ANTITUBERCULAR ACTIVITY OF 1, 3, 4-OXADIAZOLE DERIVATIVES

Asian Journal of Pharmaceutical and Clinical Research
Objective: The present study aimed to design, synthesize, and evaluate two novel series of 1,3,4-oxadiazole derivatives for their antitubercular activity against Mycobacterium tuberculosis H37Rv, supported by molecular docking and absorption, bio-distribution, metabolism, and excretion (ADME) predictions to identify potential lead molecules.
null NAMITHA KN, null VELMURUGAN V
openaire   +1 more source

Sy nthesis of Some New Schifrs-Bases Derived From 2-(4-m ethoxy phenyl)-5- (4-amino phenyl)-1,3,4-0xadiazole

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
A new compound  2-(4-methoxyphcnyl)-5-(4-aminophenyl)-1,3,4- oxadiazole (VI) was prepared by intramol ecular condensation reaction followed  by elimination  of some simple  moieties such  as IhO  and HCI by using  POCI3 with acid hydrazide.
J. H Tomma
doaj  

Inhibition of Acetylcholinesterase with Novel 1, 3, 4, Oxadiazole Derivatives: A Kinetic, In Silico, and In Vitro Approach. [PDF]

ACS Omega, 2023
Begum F, Yousaf M, Iqbal S, Ullah N, Hussain A, Khan M, Khalid A, Algarni AS, Abdalla AN, Khan A, Lodhi MA, Al-Harrasi A.   +11 more
europepmc   +1 more source

Safer and Convenient Synthesis of 3,4-Bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole-2-oxide (BNFF/DNTF)

A safer, convenient, and scalable synthesis for 3,4-bis­(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole-2-oxide (BNFF or DNTF) is described. The obtained products were fully characterized and further confirmed by single-crystal X-ray diffraction.
Shuaiqi Wang (8196252), Pengcheng Wang (400334), Ming Lu (122276), Yuangang Xu (6320300), Dongxue Li (835305), Qiuhan Lin (4517425)   +5 more
core   +1 more source