Results 11 to 20 of about 11,638,573 (298)

Syntheses, Evaluation and Characterization of Some 1, 3, 4‐Oxadiazoles as Antimicrobial Agents [PDF]

Journal of Chemistry, 2009
1,3,4‐Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4‐oxadiazole is popularly known for its antimicrobial, anti‐inflammatory, pesticidal and antihypertensive activities etc. It is well known that the synthesis of heterocyclic compounds tend to contain multi‐structure in a molecule.
Niti Bhardwaj, S. K. Saraf, Pankaj Sharma, Pradeep Kumar   +3 more
openaire   +4 more sources

A Family of Energetic Materials Based on 1,2,4-Oxadiazole and 1,2,5-Oxadiazole Backbones With Low Insensitivity and Good Detonation Performance

Frontiers in Chemistry, 2020
Design and synthesis of new compounds with both high detonation performances and good safety properties have always been a formidable task in the field of energetic materials.
Qi Xue, Fu-qiang Bi, Jun-lin Zhang, Zi-jun Wang, Zi-jun Wang, Lian-jie Zhai, Lian-jie Zhai, Huan Huo, Bo-zhou Wang, Sheng-yong Zhang, Sheng-yong Zhang   +10 more
doaj   +2 more sources

Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives [PDF]

E-Journal of Chemistry, 2011
The syntheses of series of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR, 1H-NMR and Mass spectral data.
P. Panneerselvam, G. Geete Ganesh
doaj   +2 more sources

Activity Profiling of Nitro-Substituted Di(Hetero)Aryl 1,3,4- and 1,2,4-Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential. [PDF]

Arch Pharm (Weinheim)
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Šikorová E, Štěpánková Š, Frýbová E, Konečná K, Korbielová J, Švarcová M, Janďourek O, Pflégr V, Bősze S, Krátký M.   +9 more
europepmc   +2 more sources

Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design. [PDF]

Angew Chem Int Ed Engl
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK.   +6 more
europepmc   +3 more sources

Synthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents

Pharmaceuticals, 2021
A library of 1,2,3-triazole-incorporated thymol-1,3,4-oxadiazole derivatives (6–18) hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8, 9, 10, and 11 exhibited significant antiproliferative activity.
Abdulraheem S. A. Almalki, Syed Nazreen, A. Malebari, N. Ali, A. Elhenawy, Abdullah A. A. Alghamdi, Abrar Ahmad, S. Y. Alfaifi, M. Alsharif, Mohammad Mahboob Alam   +9 more
semanticscholar   +1 more source

Synthesis and Antimicrobial Screening of Some New Thiazole Substituted 1,3,4-Oxadiazole Derivatives

Chemistry Proceedings, 2021
In the present work, the synthesis and antimicrobial activity of new thiazole substituted 1,3,4-oxadiazole derivatives was achieved. The reaction of different thioamides with ethyl 4-chloro-3-oxobutanoate (4-chloro ethyl acetoacetate) provided ethyl 2-(2-
Siddhant V. Kokate, Sachin V. Patil
doaj   +1 more source

Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies

Pharmaceuticals, 2021
A library of novel naproxen based 1,3,4-oxadiazole derivatives (8–16 and 19–26) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized hybrids, compound2-(4-((5-((S)-1-(2-methoxynaphthalen-6-yl)ethyl)-1,3,4-oxadiazol-
Mohammad Mahboob Alam, Syed Nazreen, Abdulraheem S. A. Almalki, A. Elhenawy, Nawaf I. Alsenani, S. E. Elbehairi, A. Malebari, M. Alfaifi, M. Alsharif, S. Y. Alfaifi   +9 more
semanticscholar   +1 more source

Syntheses, crystal structures and Hirshfeld surface analysis of 2-(benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole and 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compounds were synthesized by alkylation of 5-[(4-dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiol with benzyl chloride or 2-chloro-6-fluorobenzyl chloride in the presence of potassium carbonate.
Rasul Ya. Okmanov, Abdukhakim A. Ziyaev, Azimboy Sh. Abdukarimov, Turdibek T. Toshmurodov, Tursunali S. Kholikov   +4 more
doaj   +1 more source

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives

Pharmaceuticals, 2021
In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized.
C. Stecoza, G. Nițulescu, C. Draghici, M. Cǎproiu, O. T. Olaru, M. Bostan, M. Mihăilă   +6 more
semanticscholar   +1 more source