Results 261 to 270 of about 11,638,573 (298)

1, 2, 4-Oxadiazoles

1976
Publisher Summary This chapter focuses on the chemistry of 1,2,4-oxadiazoles and the corresponding reduced derivatives. The chapter discusses the synthesis of 1,2,4-oxadiazoles. Two widely used general methods of synthesizing 1,2,4-oxadiazoles embrace 95% of the practical preparations of these compounds: The conversion of amidoximes by means of ...
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Investigation of 1, 3, 4-Oxadiazole Scaffold as Potentially Active Compounds

International Journal of Drug Design and Discovery, 2011
In the present work, various Schiff’s bases of isoniazid bearing 1, 3, 4-oxadiazole nucleus were synthesized. These compounds were purified, characterized and evaluated in vitro for antibacterial, antifungal and antiviral activities. Compound 5 showed better biological profile.
Rakesh R. Somani, Anuj G. Agrawal, Pushkar P. Kalantri, Pratibha S. Gavarkar, Erik De Clercq   +4 more
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Greener Synthesis of some Bioactive 2, 5-Disubstituted-1, 3, 4-Oxadiazoles

Research Journal of Pharmacy and Technology, 2016
In the present paper, a series of substituted 1,3,4-oxadiazoles have been synthesized by three different methods i.e. conventional heating, microwave irradiation method 1 and microwave irradiation method 2. Conventional heating, microwave irradiation method 1 and microwave irradiation method 2 were compared in terms percent yield, reaction time ...
Parin K. Vora, Rakesh R. Somani, adhuri H. Jain, Sonali S. Parab, Pallavi M. Patil   +4 more
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Synthesis of arylethylene derivatives of 2, 5-diphenyl-1, 3, 4-oxadiazole

Chemistry of Heterocyclic Compounds, 1971
The synthesis of arylethylene derivatives of 2,5-diphenyl-1,3,4-oxadiazole by the Wittig reaction from 2-(p-bromomethylphenyl)-5-phenyl-1,3,4-oxadiazole and aromatic aldehydes is described. The compounds obtained fluoresce strongly on irradiation with UV light.
B. M. Krasovitskii, V. I. Grigor'eva
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Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents

2021
In the present investigation a new series of 1, 3, 4-oxadiazoles (3a-j) were synthesized by reacting INH (1) and substituted aromatic acids (2) in presence of POCl3. The new compounds were established on the basis of IR, 1H NMR and Mass spectral data.
B. C. Revanasiddappa, E. V. S. Subrahmanyam   +1 more
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Pharmacophore studies of 1, 3, 4-oxadiazole nucleus: Lead compounds as α-glucosidase inhibitors

Food and Chemical Toxicology, 2019
α-glucosidase inhibition is a rational approach in the effective management of type 2 diabetes. Several inhibitors of this enzyme class are in clinical use, but are riddled with efficacy, potency and safety challenges. For this reason, new effective α-glucosidase inhibitors are under investigation.
Haroon Khan, Muhammad Zafar, Seema Patel, SM Mukarrum Shah, Anupam Bishayee   +4 more
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Synthesis and biological evaluation of 1, 2, 4‐oxadiazole derivatives as novel GPR119 agonists

Chemical Biology & Drug Design, 2016
A series of 1, 2, 4‐oxadiazole derivatives have been designed and synthesized, and 25 compounds were evaluated their abilities by the assay of cAMP concentration in GPR119‐transfected HEK293T cells. All compounds showed acceptable agonistic effects on GPR119. Among these compounds, 4p exhibited the best agonistic effects with the EC50 of 20.6 nm, which
Suhong, Fu, Wei, Xiang, Jinying, Chen, Liang, Ma, Lijuan, Chen   +4 more
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Anti-inflammatory potentials of some novel Murrayanine containing 1, 3, 4-Oxadiazole derivatives

Asian Journal of Pharmacy and Technology, 2018
Based on the assumption that designing compounds with all the three features; a natural product, a synthetic component, and a functional Schiff’s base will surely lead to the development of more potent and safe analogs. The present research endeavors at designing a novel molecule from a previously reported starting material ( E )-2-((1-methoxy-9H ...
Debarshi Kar Mahapatra, Ruchi S. Shivhare, Vinod G. Ugale   +2 more
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Combinations of furoxan and 1,2,4-oxadiazole for the generation of high performance energetic materials.

Dalton Transactions, 2019
Several energetic materials, which are composed of furoxan and 1,2,4-oxadiazole backbones, were synthesized by nitrating 3,3'-bis(5-amino-1,2,4-oxadiazol-3-yl)-4,4'-azofuroxan (2) under 100 wt% HNO3 or 100 wt% HNO3/Ac2O followed by a cation metathesis ...
Hualin Xiong, Hongwei Yang, Caijin Lei, P. Yang, Wei Hu, G. Cheng   +5 more
semanticscholar   +1 more source

Protection of mild steel in hydrochloric acid using methyl benzimidazole substituted 1, 3, 4-oxadiazole: computational, electroanalytical, thermodynamic and kinetic studies

Journal of Adhesion Science and Technology, 2019
The corrosion protection efficiency of MBIMOT, 5-((2-methyl-1H-benzo[d]imidazol-1-yl) methyl)-1, 3, 4 oxadiazole-2-thiol towards mild steel (MS) in HCl and its variation with inhibitor concentration, acid concentration and temperature were assessed by ...
Rugmini Ammal P, Anupama R Prasad, R. K., S. John, A. Joseph   +4 more
semanticscholar   +1 more source