Results 21 to 30 of about 11,638,573 (298)

Synthesis and Screening of New [1,3,4]Oxadiazole, [1,2,4]Triazole, and [1,2,4]Triazolo[4,3-b][1,2,4]triazole Derivatives as Potential Antitumor Agents on the Colon Carcinoma Cell Line (HCT-116)

open access: yesACS Omega, 2021
New derivatives of [1,3,4]oxadiazole-2-thione and triazole-3-thione were synthesized through the cyclocondensation of dicarbonyl ester 2 with phenyl hydrazine followed by hydrazinolysis to give the corresponding hydrazide, which reacted with carbon ...
El-sayed M. Abdelrehim
semanticscholar   +1 more source

1,3,4-Oxadiazole N-Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities

open access: yesMolecules, 2021
The reaction of 5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione 3 with formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in ethanol at room temperature yielded the corresponding N-Mannich bases 3-arylaminomethyl-5-(3,4-
L. Al-Wahaibi   +4 more
semanticscholar   +1 more source

Inhibition Evaluation of 5-(4-(1H-pyrrol-1-yl)phenyl)-2-mercapto-1,3,4-oxadiazole for the Corrosion of Mild Steel in an Acidic Environment: Thermodynamic and DFT Aspects

open access: yesTribologia - Finnish Journal of Tribology, 2021
In this investigation, an oxadiazole namely 5-(4-(1H-pyrrol-1-yl)phenyl)-2-mercapto-1,3,4-oxadiazole (PMO), was synthesized and explored as an inhibitor against the corrosion  of mild steel in 1.0 M hydrochloric acid environment at various solution ...
A. Mustafa   +6 more
semanticscholar   +1 more source

Synthesis of 5-substituted-1,3,4-oxadiazole clubbed pyrazole and dihydropyrimidine derivatives as potent bioactive agents

open access: yesEuropean Chemical Bulletin, 2021
A series of 4-fluorophenylpyrazole clubbed 1,3,4-oxadiazole and 3,4-dihydropyrimidin-2(1 H )-ones were prepared by cyclization of Biginelli-type adducts. Structures were assigned on the basis of known spectral techniques. All the scaffolds were evaluated
B. Patel   +2 more
semanticscholar   +1 more source

4,4′-Difluoro-[3,3′-bi(1,2,5-oxadiazole)] 2,2′-Dioxide

open access: yesMolbank, 2023
1,2,5-Oxadiazole oxides (furoxans) are well known nitric oxide donors; among them, 4-fluorofuroxans have recently been found to be important photoinduced nitric oxide donors. In this research, it was shown that the reaction of 4,4′-dinitro-[3,3′-bi(1,2,5-
Natalia V. Obruchnikova, Oleg A. Rakitin
doaj   +1 more source

Synthesis and pesticidal activity of new 1,3,4-oxadiazole thioether compounds containing a trifluoromethylpyrazoyl moiety

open access: yesResearch on chemical intermediates (Print), 2022
In order to find new lead compounds with high pesticidal activity, a series of 1,3,4-oxadiazole thioether compounds (5 series) were designed by using penthiopyrad as a synthon.
Haining Shi   +8 more
semanticscholar   +1 more source

N-Phenyl-N-{4-[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl}aniline

open access: yesActa Crystallographica Section E, 2008
The title compound, C25H18N4O, is a non-planar bipolar ligand containing triphenylamine and 1,3,4-oxadiazole units. In the molecule, the benzene ring, the 1,3,4-oxadiazole ring, and the pyridine ring are twisted slightly with respect to each other ...
Li-Ping Han, Bin Li, Jie Liu
doaj   +1 more source

Synthesis and assessment of the cytotoxic effect of some of 1,4-dihydropyridine derivatives which contain azole moiety [PDF]

open access: yesJournal of the Serbian Chemical Society, 2021
A number of 1,4-dihydropyridine derivatives (9a–d, 10a–d and 11a–d) were designed and synthesized by the reaction of 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones to 2,6-dibromomethyl-3,5-diethoxycarbonyl-4-(3- -nitrophenyl)-1,4-dihydropyridine.
Ghoorbannejad Saeed   +2 more
doaj   +1 more source

Glycogen phosphorylase inhibitor N-(3,5-dimethyl-benzoyl)-N'-(β-Dglucopyranosyl) urea improves glucose tolerance under normoglycemic and diabetic conditions and rearranges hepatic metabolism [PDF]

open access: yes, 2013
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes.
Bai, Péter   +10 more
core   +5 more sources

3-(4-Amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole

open access: yesMolbank, 2014
The title compound 3-(4-amino-1,2,5-oxadiazol-3-yl)-4-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (ANFF-1) was synthesized by: (1) by reaction of 3,4-bis(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole (BNFF-1) with gaseous ammonia in toluene and (2)
Philip Pagoria   +5 more
doaj   +1 more source

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