Results 51 to 60 of about 5,785 (211)

Poly(1,3,4-oxadiazoles) via aromatic nucleophilic displacement [PDF]

open access: yes, 1992
Poly(1,3,4-oxadiazoles) (POX) are prepared by the aromatic nucleophilic displacement reaction of di(hydroxyphenyl) 1,3,4-oxadiazole monomers with activated aromatic dihalides or activated aromatic dinitro compounds. The polymerizations are carried out in
Connell, John W.   +2 more
core   +1 more source

Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions

open access: yesDrug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Ahmet Bugra Aksel   +9 more
wiley   +1 more source

Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters

open access: yesMolecules, 2011
A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole ...
Aurangzeb Hasan   +2 more
doaj   +1 more source

Synthesis, biological evaluation and molecular docking studies of Mannich bases derived from 1, 3, 4-oxadiazole- 2-thiones as potential urease inhibitors [PDF]

open access: yes, 2018
Purpose: To design and synthesize a series of new structural motifs of urease inhibitors, 3-[{(substituted phenyl) amino} methyl]-5-(3, 4, 5-trimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thiones and 3- {[(pyridin-2-yl)amino]methyl}-5-(3,4,5-trimethoxy phenyl)-
Ahmed, Faiz   +7 more
core   +2 more sources

Cobalt‐Salen Catalysed Hydration of Alkenes With Water: A Complementary Ionic Approach to the Mukaiyama Hydration

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
A cobalt‐salen catalysed hydration of olefins with water is reported, resulting in Markovnikov alcohol products. The reaction proceeds rapidly under mild conditions and exhibits excellent functional group tolerance, supporting a wide range of styrenyl and non‐activated alkenes.
David G. Groves   +3 more
wiley   +1 more source

Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid

open access: yesمجلة بغداد للعلوم, 2016
In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and ...
Baghdad Science Journal
doaj   +1 more source

Molecular Docking Studies of 2-Mercapto-5-(3-Methoxyphenyl) 1, 3, 4 Oxadiazole Thiones with Focal Adhesion Kinase [PDF]

open access: yes, 2014
The main objective of the present work is to perform molecular docking studies of the ligand 2- Mercapto-5-(3-Methoxy phenyl) 1,3,4 oxadiazole with protein focal adhesion kinase. A good correlation was observed in binding affinity of this complex.
Guruprasad, R.   +2 more
core  

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

open access: yesArchiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi   +17 more
wiley   +1 more source

Inhibition Effect of N, N'-Dimethylaminoethanol on the Corrosion of Austenitic Stainless Steel Type 304 [PDF]

open access: yes, 2012
The effect of N,N'-dimethylaminoethanol on the corrosion of austenitic stainless steel type 304 in 3M H2SO4 has been studied by weight-loss method and linear polarization measurement in different concentrations of the compound.
Fedotova, T., Loto, C. A., Loto, R. T.
core   +1 more source

In silico design, synthesis , DFT and Antimicrobial evaluation of some 2,5 substituted 1,3,4,Oxadiazole derivatives [PDF]

open access: yes, 2017
In the present study, simple fourteen 2, 5 substituted 1,3,4- oxadiazole derivatives were subjected to molecular properties prediction and drug likeness by molinspriration software.
Gnanvel, S.   +3 more
core   +2 more sources

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