Results 81 to 90 of about 4,363 (249)

5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism

Molecules, 2005
5-Furan-2-yl[1,3,4]oxadiazole-2-thiol (Ia) and 5-furan-2-yl-4H-[1,2,4]-triazole-3-thiol (Ib) were synthesized from furan-2-carboxylic acid hydrazide. Mannich basesand methyl derivatives were then prepared.
A. Cansız, A. Çetin, M. Koparır   +2 more
doaj   +1 more source

Synthesis and antiviral activity of 2-3,5 dinitropheny1-5-substituted phenyl 1,3,4-oxadiazoles [PDF]

, 2020
3, 5 dinitro benzoic acid hydrazide was prepared by the hydrazinolysis of the corresponding ethyl ester. Condensation of this hydrazide with different aromatic acids in presence of POCl3 gave 2-3, 5 dinitropheny1-5-substituted pheny1 1, 3, 4-oxadiazoles.
Jyoti, Archana
core  

Exploration of Thioxolone Derivatives: Synthesis, Docking Studies, and Biological Evaluation for Antibacterial and Antidiabetic Activities

ChemistrySelect, Volume 10, Issue 38, October 13, 2025.
Thioxolone derivatives are evaluated for antibacterial and anti‐diabetic potential. Compounds T‐11, T‐12, and T‐13 exhibit potent antibacterial activity against E. coli, B. cereus, and S. aureus, with low MIC values. T‐11 and T‐3 show stronger α‐glucosidase inhibition than acarbose, while molecular docking reveals T‐13 as the strongest binder ...
Thohidjhon Khajavali SK, Satya Sree Nannapaneni, Rambabu Gundla, Naresh Kumar Katari   +3 more
wiley   +1 more source

Synthesis and Characterization of Some 1,2,4-Triazol-4-Amino Schiff Bases of Decorated Nano Reduced Graphene Oxide With 2-Naphthol-4-Sulfonic Acid as Non-Toxic Compounds [PDF]

Purpose: This research, some derivatives were Synthesis and Characterization of Some 1,2,4-triazol-4-amino Schiff Bases of Decorated Nano Reduced Graphene Oxide with 2-naphthol-4-sulfonic acid . Methodology: In by the hummer method preparing the graphene
Al-Somaidaie, Ghazwan, Mohammed, Yusra, Rashad, Safa   +2 more
core   +2 more sources

Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid [PDF]

, 2016
In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and ...
Al-Sahib, Sanaa A., Al-Zobaydi, Shatha F., Ismael, Ban Dha., Karim, Bushra   +3 more
core   +2 more sources

Advances in Xanthine Oxidase Inhibition: A Review of Potential Bioactive Synthetic Compounds

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
This review article looks at new synthetic xanthine oxidase inhibitors discovered in the last 5 years (2025–2020). It covers an analysis of the advances, structural diversity, biological potential of the molecules investigated and future prospects in drug development.
Giorgio Antoniolli, Gabriel Rodrigues de Moraes, Rafael Porreca Neves da Costa, Giovani Augusto Rosendo de Campos, Fernando Coelho   +4 more
wiley   +1 more source

Development of a Reliable Purity Method for Ataluren in a Sachet Formulation Through the Analysis of Its Stress Degradation Behavior Using HPLC, LC‐MS, and 2D‐NMR

SEPARATION SCIENCE PLUS, Volume 8, Issue 8, August 2025.
ABSTRACT Ataluren is a medication commonly used for Duchenne muscular dystrophy. Currently, it is available in granules for oral suspension. A unique reverse‐phase HPLC approach with a UV detector was established to detect and quantify ataluren and its degradation components in medicinal products. This technique utilized a phenyl hexyl stationary phase
Nagavardhana Reddy Vanga, Venkata Ratnam Kesamsetty, Kumarswamy Ummiti, Venkata Nadh Ratnakaram   +3 more
wiley   +1 more source

In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors

Molecules, 2020
Two sets of diphenyl ether derivatives incorporating five-membered 1,3,4-oxadiazoles, and their open-chain aryl hydrazone analogs were synthesized in good yields.
Tarek S. Ibrahim, Ehab S. Taher, Ebtihal Samir, Azizah M. Malebari, Ahdab N. Khayyat, Mamdouh F. A. Mohamed, Riham M. Bokhtia, Mohammed A. AlAwadh, Israa A. Seliem, Hani Z. Asfour, Nabil A. Alhakamy, Siva S. Panda, Amany M. M. AL-Mahmoudy   +12 more
doaj   +1 more source

A high‐resolution data set of fatty acid‐binding protein structures. III. Unexpectedly high occurrence of wrong ligands

Acta Crystallographica Section D, Volume 81, Issue 8, Page 451-464, August 2025.
Very high‐resolution fatty acid‐binding protein structures identified a substantial number of ligands that differ strongly from their expected structure. If different ligand chemistry is a potentially overlooked problem in other, lower resolution, crystal structures of protein–ligand complexes, it has repercussions for any study using such structures ...
Andreas Ehler, Christian Bartelmus, Joerg Benz, Inken Plitzko, Markus G. Rudolph   +4 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of 4-S-Methyl-1,3,4-Oxadiazole Derivatives of Some Natural Amino Acids Bearing Secondary Quaternary Ammonium Salt Moieties [PDF]

, 2018
Secondary quaternary ammonium salts (QAS) derived from three natural amino acids (L-Leucine, L-Phenylalanine and L-Methionine) bearing 1,3,4-oxadiazole and acetic acid moieties have been synthesized and characterized by IR, 1H and 13C NMR.
Adil, Ali Othman, Eddine, Adli Djallal, Sofiane, Daoudi, Tahar, Benaissa   +3 more
core   +1 more source