Results 51 to 60 of about 5,642 (192)

Structure of 5-Hydroxy-2-hydroxymethyl-4-pyridones [PDF]

Bulletin of the Chemical Society of Japan, 1979
Abstract 5-Hydroxy-2-hydroxymethyl-4-pyridone and its N-methyl, N-ethyl, and N-phenyl derivatives were prepared from kojic acid. The UV spectra in neutral, acid, and alkaline solutions showed that the neutral species and the conjugate acids existed in the pyridone and the pyridine form, respectively. The conjugate bases may exist in both
Kimiaki Imafuku, Makoto Ishizaka, Hisashi Matsumura   +2 more
openaire   +1 more source

Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems [PDF]

, 2015
Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriers because of their colloidal stability, tunable membrane properties and ability to encapsulate or integrate a broad range of drugs and molecules.
Bouchet, Lydia María, Brunetti, Veronica, Strumia, Miriam Cristina   +2 more
core   +1 more source

Design, synthesis, and cytotoxicity evaluation of novel indole-acylhydrazone derivatives of 4-pyridinone as potential histone deacetylase-2 inhibitors

Research in Pharmaceutical Sciences, 2022
Background and purpose: Histone deacetylation is one of the essential cellular pathways in the growth and spread of cancer, so the design of histone deacetylase (HDAC) inhibitors as anticancer agents is of great importance in pharmaceutical chemistry ...
Niloofar Naghi-Ganji, Lotfollah Saghaei, Farial Tavakoli, Vajihe Azimian, Mina Mirian, Hajar Sirous, Mahboubeh Rostami   +6 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Synthesis and chemical properties of 3-acyl- and 3-carbethoxy-4-pyrones [PDF]

, 2013
Реакция 1-арил-2-диметиламинометиленбутан-1,3-дионов с диэтиоксалатом в присутствии гидрида натрия в ТГФ приводит к образованию этил 5-ароил-4-оксо-4Н-пиран-2- карбоксилатам, из которых 4-оксо-6-арил-4Н-пиран-2-карбоновые кислота (6- арилкомановая ...
Obydennov, D. L., Обыденнов, Д. Л.   +1 more
core  

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections [PDF]

, 2016
Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently.
Alibana-Clouser, F, Antonyuk, SV, Brasseur, G, Capper, M, Donkin, D, Dovgin, S, Dubey, J, El Bissatai, K, Esaa, F, Fishwick, CWG, Fraczek, L, Gordon, J, Hasnain, S, He, Y, Hickman, M, Hood, L, Kent, M, Kim, E, Kim, TK, Lee, P, Lorenzi, H, Lukens, AK, Lykins, J, McLeod, R, McPhillie, M, Meunieur, B, Moulton, H, Muench, S, Roberts, CW, Sanders, J, Santos, T, Verma, SK, Wang, K, Weber, CR, Weiss, L, Wheeler, K, Wirth, D, Woods, S, Zhou, Y   +38 more
core   +4 more sources

Photochemistry of Aromatic N‐Oxides in Water Probed by Time‐Resolved X‐ray Absorption Spectroscopy

Chemistry – A European Journal, EarlyView.
Time‐resolved XAS at the nitrogen and oxygen K‐edges is applied to the photorearrangement of two N‐oxides in water. Pyridine N‐oxide rapidly forms the oxaziridine isomer. Pyridazine N‐oxide undergoes ring opening to the diazo compound, without any evidence of intermediates.
Maximilian Paradiz Domínguez, Robby Büchner, Mattis Fondell, Albert M. Brouwer   +3 more
wiley   +1 more source

A sensitive and rapid HPLC-DAD method for the determination of 3-hydroxy-1,2-dimethyl-4-pyridone and its distribution in rats [PDF]

, 2020
Purpose: To establish a sensitive and rapid method for the determination of the tissue distribution of 3-hydroxy-1,2-dimethyl-4-pyridone (L1) in vivo, and its plasma protein binding capacity.Methods: This study optimized a reverse-phase HPLC method for ...
Chen, Mengdi, Li, Shuling, Zhang, Qiongyao, Zhang, Xuejiao   +3 more
core   +2 more sources

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Domino-reactions of 3-methyl-5-aminopyrazole with 1-phenyl-3-(4-alkoxyphenyl)pyrazole-4-carbaldehydes and 2,2-dimethyl-1,3-dioxane-4,6-dione

Журнал органічної та фармацевтичної хімії, 2020
Aim. To synthesize 1-phenyl-3-(4-alkoxyphenyl)pyrazole-4-carbaldehydes and determine the direction of their interaction in the three-component condensation with 3-methyl-5-aminopyrazole and 2,2-dimethyl-1,3-dioxane-4,6-dione. Results and discussion. A
Olexander M. Semenenko, Victoria V. Lipson, Veronika V. Mironova, Lilia V. Budianska, Vladimir I. Musatov, Dmitro S. Sofronov   +5 more
doaj   +1 more source