Results 71 to 80 of about 5,642 (192)

Targeting cancer cell mitochondria with a multivalent source of singlet oxygen

Smart Molecules, Volume 4, Issue 1, March 2026.
Multivalent source of singlet oxygen can effectively target cancer cell mitochondria and cause improved cancer cell selective cytotoxicity at low micromolar concentrations. Abstract Naphthalene, anthracene and pyridone endoperoxides are known to thermally release singlet oxygen.
Wanwan Wang, Lei Wang, Rensong Sun, Shoucai Yan, Engin U. Akkaya   +4 more
wiley   +1 more source

Dichlorido[1-(1,10-phenanthrolin-2-yl)-2-pyridone]cadmium(II)

Acta Crystallographica Section E, 2008
In the title mononuclear complex, [CdCl2(C17H11N3O)], the CdII ion assumes a distorted trigonal–bipyramidal coordination geometry. The pyridone plane is twisted out of the 1,10-phenanthroline mean plane by 43.8 (3)°.
Jin-Min Li
doaj   +1 more source

Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Nicotinamide is an essential precursor of NAD involved in energy metabolism. A decline in NAD levels across tissues during ageing is well‐documented, and NAD metabolism has been implicated in ovarian ageing. We investigated the relationship between ovarian ageing and the levels of nicotinamide (NAM) and its metabolite 1‐methylnicotinamide (MNA)
Cinzia Bocca, Magalie Boguenet, Lisa Boucret, Pierre‐Emmanuel Bouet, Pascal Reynier, Pascale May‐Panloup   +5 more
wiley   +1 more source

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon, Hartmut Cuny, Nana Sunn, Ella M. M. A. Martin, Delicia Z. Sheng, Gavin Chapman, Sally L. Dunwoodie   +6 more
wiley   +1 more source

Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review. [PDF]

, 2011
International audienceThe metabolome is the set of small molecular mass organic compounds found in a given biological media. It includes all organic substances naturally occurring from the metabolism of the studied living organism, except biological ...
Heillier, Jean-François, Junot, Christophe, Lison, Dominique, Roux, Aurélie   +3 more
core   +2 more sources

Design, Synthesis and Anti-fibrosis Activity Study of N1-Substituted Phenylhydroquinolinone Derivatives

Molecules, 2012
Pirfenidone (5-methyl-1-phenyl-2(1H)-pyridone, PFD) is a small-molecule compound acting on multiple targets involved in pathological fibrogenesis and is effective to increase the survival of patients with fibrosis, such as idiopathic pulmonary fibrosis ...
Jun Chen, Lijian Tao, Qianbin Li, Bin Liu, Ling Wu, Gaoyun Hu   +5 more
doaj   +1 more source

Fluorine‐Free Ionic Liquid Electrolytes Featuring Biomass‐Derived Heterocyclic Anions for Variable Temperature Supercapacitors

Advanced Energy and Sustainability Research, Volume 7, Issue 2, February 2026.
This study introduces two new fluorine‐free ionic liquids (ILs) produced by coupling biomass‐derived heterocyclic anions, i.e., THP and 3‐FuA, with P4444 cation. Both the ILs display enhanced capacitance with increasing temperature, underscoring their potential as fluorine‐free electrolytes for supercapacitors.
Gaurav Tatrari, Sayantika Bhakta, Mukhtiar Ahmed, Solomon Tesfalidet, Faiz Ullah Shah   +4 more
wiley   +1 more source

Synthesis of α‐Pentafluorosulfanylated‐β2,3‐Amino Esters

ChemistryEurope, Volume 4, Issue 2, February 2026.
De novo α‐SF5‐β2,3‐amino esters are now accessible through a straightforward aza‐Michael reaction using a series of newly developed (E)‐α‐SF5‐α,β‐unsaturated esters. Two new, highly functionalized, contiguous tertiary stereocenters are formed with diastereodivergence governed by the choice of solvent and/or base.
Thi Mo Nguyen, Guilhem Colomer, Oscar Maugue‐Sauze, Nicolas Blanchard, Vincent Bizet, Dominique Cahard   +5 more
wiley   +1 more source

A New Convenient Synthesis of Functionalized 2,3‐Dihydro‐4‐pyridones.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Svetlik, Jan, Kettmann, Viktor, Zaleska, Barbara   +2 more
openaire   +2 more sources

19F NMR as a Molecular Reporter: Labelling Strategies and Methods for Probing Biomolecular Motion and Exchange

Chemistry–Methods, Volume 6, Issue 2, February 2026.
This review summarizes the unique benefits 19F NMR spectroscopy has to offer for the study of biological systems. Particular focus is laid on the available strategies for incorporation of fluorinated probes into proteins and the latest applications of the ever‐expanding toolbox of fluorine NMR methodology to study structure and dynamics.
Charles Burridge, Björn M. Burmann
wiley   +1 more source