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4-pyridoxic acid 5′-phosphate: A metabolite of pyridoxol in the rat

Biochemical and Biophysical Research Communications, 1970
Abstract An unknown labelled compound found in rat tissues and urine after the administration of 14 C-pyridoxol has been identified as 4-pyridoxic acid 5′-phosphate. It was not an artifact caused by the extraction and separation techniques employed. The results suggest that tissue pyridoxal phosphate is oxidised to pyridoxic acid phosphate which is ...
S F Contractor, B Shane
exaly   +3 more sources

Measurement of pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children

Clinica Chimica Acta, 2017
We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in the cerebrospinal fluid (CSF) of children and to investigate the effect of age, sex, epilepsy, and anti-epileptic drug (AED) therapy on these vitamers.CSF samples prospectively collected from 116 pediatric patients were analyzed. PLP, PL, and PA were measured using
Tomoyuki Akiyama   +2 more
exaly   +3 more sources

URINARY VITAMIN B6 AND 4-PYRIDOXIC ACID IN HEALTH AND IN VITAMIN B6 DEPENDENCY

Pediatrics, 1965
The urinary excretion of vitamin B6 and 4-pyridoxic acid was studied in normal children and adults and in children with the vitamin B6dependency syndrome. There were no differences in the relative proportions of free and hydrolyzable vitamin B6 and of 4-PDA excreted by normal and by vitamin B6-dependent subjects.
Scriver Charles R
exaly   +3 more sources

Optical measurement of 4-pyridoxic acid in the spent dialysate: Algorithm Development

2016 15th Biennial Baltic Electronics Conference (BEC), 2016
The aim of this study was to develop an algorithm suitable for the estimation of 4-pyridoxic acid (4PA) concentration removed during dialysis through fluorescence measurements in spent dialysate. 4PA is the major urinary catabolite of vitamin B-6 (B6), that is regularly injected to dialysis patients.
Risto Tanner   +2 more
exaly   +2 more sources

A simple, sensitive and reproducible assay for pyridoxal 5′-phosphate and 4-pyridoxic acid in human plasma

Clinica Chimica Acta, 1999
We describe a procedure for the measurement of pyridoxal 5'-phosphate and of 4-pyridoxic acid in human plasma samples. It is based on the conversion of pyridoxal 5'-phosphate to 4-pyridoxic acid 5'-phosphate by cyanide in alkaline medium, followed by a high pressure liquid chromatographic separation, with fluorescence detection at acid pH. The assay is
Christopher J Bates   +2 more
exaly   +3 more sources

Pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children

Clinica Chimica Acta, 2017
We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers.Serum and CSF samples prospectively collected from 49 pediatric patients were analyzed.
Tomoyuki Akiyama   +2 more
exaly   +3 more sources

Determination of urinary 4-pyridoxic acid levels as 4-pyridoxic acid lactone using high-performance liquid chromatography

The American Journal of Clinical Nutrition, 1986
A high-performance liquid chromatography method for quantitation of urinary 4-pyridoxic acid excretion is presented. Urine samples were treated with HCl to form 4-pyridoxic acid lactone. Acid-treated urine samples were diluted and analyzed by cation-exchange chromatography involving post-column alkalinization and fluorescence detection.
J B, Ubbink   +3 more
openaire   +2 more sources

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