Results 1 to 10 of about 1,162 (142)

4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores [PDF]

Diagnostics, 2019
Background: Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk ...
Rima Obeid, Juergen Geisel, Wilfred A. Nix   +2 more
doaj   +4 more sources

Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Pyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur, Sumathy Mathialagan, Emi Kimoto, Manthena V. S. Varma   +3 more
doaj   +3 more sources

A one-step NIST traceable HPLC method for quantitation of vitamin B6 and 4-pyridoxic acid in human plasma [PDF]

Practical Laboratory Medicine, 2020
Objectives: Vitamin B6 deficiency is associated with a wide spectrum of clinical syndromes. While vitamin B6 status is primarily assessed by measuring the biologically active form of the vitamin, pyridoxal 5-phosphate (PLP), concurrent measurement of the
Xiaochun Zhang, Xiaoying Tang, Thomas M. Daly   +2 more
doaj   +4 more sources

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2021
Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs).
Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami‐Hodjegan, Aleksandra Galetin   +6 more
doaj   +2 more sources

4-Pyridoxic Acid in the Spent Dialysate: Contribution to Fluorescence and Optical Monitoring. [PDF]

PLoS ONE, 2016
In this work we estimated the contribution of the fluorescence of 4-pyridoxic acid (4-PA) to the total fluorescence of spent dialysate with the aim of evaluating the on-line monitoring of removal of this vitamin B-6 metabolite from the blood of patients ...
Sigrid Kalle, Risto Tanner, Jürgen Arund, Ruth Tomson, Merike Luman, Ivo Fridolin   +5 more
doaj   +2 more sources

Integrated metagenomic and metabolomic profiling of spontaneous preterm birth in Chinese women [PDF]

Frontiers in Microbiology
BackgroundSpontaneous preterm birth (sPTB) remains a major cause of neonatal morbidity and mortality. We used integrated metagenomics and untargeted metabolomics to identify vaginal microbial and host metabolic signatures associated with sPTB in Chinese ...
Heng Xue, Mengjun Zhang, Yao Tang, Wu Huang, Xingliang Yu, Xingliang Yu, Jun Zhang, Mian Pan, Zhaodong Liu   +8 more
doaj   +2 more sources

Establishment of age-stratified serum vitamin B6 pyridoxal and pyridoxic acid reference intervals among children aged 1–16 years in Henan, china [PDF]

Frontiers in Nutrition
Background/ObjectiveThe development of population-specific reference intervals (RIs) for serum vitamin B6 (B6) in Chinese pediatric populations has not been established.
Yusheng Luan, Nan Chen, Xucheng Wang, Xiaojuan Li, Junmei Yang, Tiewei Li   +5 more
doaj   +2 more sources

Maternal metabolic signatures at early gestation associated with birth weight and neurodevelopment in early childhood [PDF]

Communications Medicine
Background Emerging evidence suggests that maternal factors during pregnancy can exert effects on offspring. However, the underlying metabolic associations remain insufficiently understood.
Jun Yang, Xiaojing Zeng, Qi Li, Xiaolin Wang, Yuting Wang, Qianlong Zhang, Guowang Xu, Jun Zhang, Xinyu Liu   +8 more
doaj   +2 more sources

Exploratory Analysis of Gut Microbiome and Metabolic Profile Changes Following Lenvatinib and Anti-PD-1 Combination Therapy in Liver Cancer [PDF]

Metabolites
Background/Objectives: Lenvatinib combined with anti-PD-1 therapy has shown promise in the treatment of hepatocellular carcinoma (HCC). The study evaluates changes in gut microbiota (GM) and metabolites during HCC treatment with lenvatinib combined with ...
Rui Zhong, Zhikun Lin, Binghui Jin, Xiaolin Wang, Hua Mu, Jinlong Hu, Qi Li, Peng Dou, Xinyu Liu, Chunxiu Hu, Guowang Xu, Guang Tan   +11 more
doaj   +2 more sources

Age- and sex-specific reference intervals and determinants of plasma vitamin B6 metabolites in healthy Chinese adults [PDF]

Frontiers in Nutrition
ObjectiveReference intervals (RIs) for vitamin B6 biomarkers remain underexplored in Chinese adults. We aimed to establish age- and sex-specific RIs of pyridoxal 5′-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (PA), and their ratios (PLP/PL, PLP/PA,
Yazhao Mei, Ziyuan Wang, Li Shen, Zhenlin Zhang, Hua Yue, Hao Zhang, Jiemei Gu, Weiwei Hu, Shanshan Li, Chao Gao, Zhe Wei, Yang Xu, Jie Wang, Gao Gao, Chun Wang   +14 more
doaj   +2 more sources