Results 21 to 30 of about 1,181 (159)

Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study

BMC Neurology, 2021
Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required.
Katinka Nordheim Alme, Torunn Askim, Jörg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Næss, Ingvild Saltvedt, Per-Magne Ueland, Arve Ulvik, Anne-Brita Knapskog   +9 more
doaj   +1 more source

Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke

BMC Neurology, 2021
Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation associated with sedentary ...
Katinka Nordheim Alme, Arve Ulvik, Torunn Askim, Jörg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Næss, Ingvild Saltvedt, Per-Magne Ueland, Anne-Brita Knapskog   +9 more
doaj   +1 more source

Metabolomics analysis of the saliva in patients with chronic hepatitis B using nuclear magnetic resonance: a pilot study [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Hepatitis B virus infection causes chronic disease such as cirrhosis and hepatocellular carcinoma. The metabolomics investigations have been demonstrated to be related to pathophysiologic mechanisms in many disorders such as hepatitis B ...
Kambiz Gilany, Ashraf Mohamadkhani, Saeed Chashmniam, Parisa Shahnazari, Mehdi Amini, Babak Arjmand, Reza Malekzadeh, Bibi Fatemeh Nobakht Motlagh Ghoochani   +7 more
doaj   +1 more source

Urinary Metabolites Enable Differential Diagnosis and Therapeutic Monitoring of Pediatric Inflammatory Bowel Disease

Metabolites, 2021
Rates of pediatric Crohn’s disease (CD) and ulcerative colitis (UC) are increasing globally. Differentiation of these inflammatory bowel disease (IBD) subtypes however can be challenging when relying on invasive endoscopic approaches.
Mai Yamamoto, Meera Shanmuganathan, Lara Hart, Nikhil Pai, Philip Britz-McKibbin   +4 more
doaj   +1 more source

Inulin and Chinese Gallotannin Affect Meat Quality and Lipid Metabolism on Hu Sheep

Animals, 2022
The aim of this study was to investigate the impacts of inulin and Chinese gallotannin on the meat fatty acids and urinary metabolites in sheep. Twenty-four healthy (25.80 ± 3.85 kg) weaned Hu lambs of approximately 4.5 months old were equally divided ...
Zhaohua He, Long Cheng, Shaobin Li, Qiaoling Liu, Xue Liang, Jiang Hu, Jiqing Wang, Xiu Liu, Fangfang Zhao   +8 more
doaj   +1 more source

Population Physiologically-Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions. Ethical concerns often limit clinical pharmacology studies that have no direct therapeutic benefit in children, highlighting the value of PBPK model predictions.
Cleary Y, Prasad B, Ogungbenro K, Gertz M, Galetin A.   +4 more
europepmc   +2 more sources

Abnormal bile acid metabolism is an important feature of gut microbiota and fecal metabolites in patients with slow transit constipation

Frontiers in Cellular and Infection Microbiology, 2022
Destructions in the intestinal ecosystem are implicated with changes in slow transit constipation (STC), which is a kind of intractable constipation characterized by colonic motility disorder.
Yadong Fan, Chen Xu, Lulu Xie, Ying Wang, Shan Zhu, Jiren An, Yuwei Li, Zhikui Tian, Yiqi Yan, Shuang Yu, Haizhao Liu, Beitian Jia, Yiyang Wang, Li Wang, Long Yang, Long Yang, Yuhong Bian   +16 more
doaj   +1 more source

The oxidation of Schiff bases of pyridoxal and pyridoxal phosphate with amino acids by manganous ions and peroxidase [PDF]

Biochemical Journal, 1966
1. Oxygen was taken up rapidly when pyridoxal or pyridoxal phosphate was added to mixtures of pea-seedling extracts and Mn(2+) ions. 2. The increases in total oxygen uptake were proportional to the pyridoxal or pyridoxal phosphate added and were accompanied by the disappearance of these compounds. 3.
Hill, J. M., Mann, P. J. G.
openaire   +2 more sources

Distinct Gut Microbiota and Metabolite Profiles Induced by Different Feeding Methods in Healthy Chinese Infants

Frontiers in Microbiology, 2020
Human milk is closely correlated with infant gut microbiota and is important for infant development. However, most infants receive exclusively insufficient breast milk, and the discordance between effects of commercial formula and human milk exists.
Na Li, Na Li, Fenfen Yan, Fenfen Yan, Nana Wang, Nana Wang, Yue Song, Yue Song, Yingxue Yue, Yingxue Yue, Jiaqi Guan, Jiaqi Guan, Bailiang Li, Bailiang Li, Guicheng Huo, Guicheng Huo   +15 more
doaj   +1 more source

Milk metabolome reveals pyrimidine and its degradation products as the discriminant markers of different corn silage-based nutritional strategies

Journal of Dairy Science, 2022
: The purpose of this study was to evaluate the effect of 6 different feeding systems (based on corn silage as the main ingredient) on the chemical composition of milk and to highlight the potential of untargeted metabolomics to find discriminant marker ...
G. Rocchetti, F. Ghilardelli, E. Carboni, A.S. Atzori, F. Masoero, A. Gallo   +5 more
doaj   +1 more source