Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs [PDF]
, 2014 Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy.
Wang, Xin
core +1 more source
Spektrofluorimetrijsko određivanje ciklopiroks olamina prevođenjem u ternarni kompleks s Tb(III) i EDTA [PDF]
, 2006 A highly sensitive and selective spectrofluorimetric method was developed for the determination of ciclopirox olamine in raw material and in dosage forms.
MANAL IBRAHIM EID +3 more
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Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. [PDF]
, 2020 Lyme disease is one of most common vector-borne diseases, reporting more than 300,000 cases annually in the United States. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. However, 10-20% of patients
Ahmed, Mohamed Sohail +7 more
core
Dependence of norfloxacin diffusion across bilayers on lipid composition. [PDF]
, 2015 Antibiotic resistance is a growing concern in medicine and raises the need to develop and design new drug molecules that can efficiently inhibit bacterial replication. Spurring the passive uptake of the drug molecules is an obvious solution.
Cama, Jehangir +2 more
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Synthesis and Anticancer Activity of 3,4-Diaryl-1,2-dihydro- and 1,2,3,4-Tetrahydroquinolines
MoleculesTetrahydroquinolines are key structures in a variety of natural products with diverse pharmacological utilities and other applications. A series of 3,4-diaryl-5,7-dimethoxy-1,2,3,4-tetrahydroquinolines were synthesized in good yield by reacting 3-aryl-5 ...
Santosh Rajput +4 more
doaj +1 more source
E-Journal of Chemistry, 2011 Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV.
Eskandar Alipour +6 more
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Laboratory Survey of Fluoroquinolone Activity [PDF]
, 2017 Fluoroquinolones are active against a wide variety of bacteria. The antibacterial spectra of fluoroquinolones encompass staphylococci, Bacillus species, and Corynebacterium species implicated in infections of the immunocompromised host ...
Bellido, Francis, Pechère, Jean-Claude
core
Modulation of host biology by Pseudomonas aeruginosa quorum sensing signal molecules: messengers or traitors [PDF]
, 2015 YesBacterial cells sense their population density and respond accordingly by producing various signal molecules to the surrounding environments thereby trigger a plethora of gene expression. This regulatory pathway is termed quorum sensing (QS).
Aendekerk +85 more
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Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS) [PDF]
, 2022 Joy Ogbechi +7 more
openalex +1 more source
Regiocontrolled Nitration of 4-Quinolones at Ambient Conditions
, 2015 Regiocontrolled nitration of 4-quinolone, the highly privileged scaffold, has been developed at ambient conditions. The nitro group can selectively be introduced at diverse positions simply by tuning the reactivity of the moiety.
Sonali Sarkar +3 more
semanticscholar +1 more source