Results 121 to 130 of about 34,010 (190)

Microbiome‐Based Modeling of CAR‐T Therapy Response in Lymphoma: Insights From Shotgun Metagenomics Sequencing

European Journal of Haematology, Volume 116, Issue 5, Page 646-662, May 2026.
ABSTRACT The interplay between the commensal microbiota and the mammalian immune system may influence the outcomes of T cell‐driven cancer immunotherapies. However, clinical studies supporting microbiota‐based interventions in chimeric antigen receptor T‐cell (CAR‐T) therapy remain scarce.
Rafael Hernani, Eliseo Albert, Carlos Hernani‐Morales, Sheila Zúñiga, Ana Benzaquén, Laura González‐Castillo, Ester Colomer, Júlia Morell, José Francisco Català‐Senent, José Luis Piñana, Estela Giménez, Ariadna Pérez, Juan Carlos Hernández‐Boluda, Ignacio Arroyo, Marcos Rivada, Teresa Barber, Teresa Alemany, Enric Santacatalina, Pilar Rentero‐Garrido, María José Terol, Rafael Díaz, David Navarro, Carlos Solano   +22 more
wiley   +1 more source

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems

Results in Chemistry
Synthesis of analogs of known active compounds is the most often employed strategy for producing important compounds. The Hantzsch reaction was employed to create new star-shaped compounds with a pentaerythritol core connected to thiazoles ...
Hadeer M. Diab, Ismail A. Abdelhamid, Mostafa E. Salem, Islam Ragab, Magdi E.A. Zaki, Amr M. Abdelmoniem, Ahmed H.M. Elwahy   +6 more
doaj   +1 more source

Direct Introduction of Fluorocyclopropyl Groups via Energy Transfer Catalysis

Advanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.
This work describes an efficient, straightforward protocol for the direct incorporation of fluorinated cyclopropyl moieties via energy‐transfer catalysis. The method unlocks access to a broad range of previously inaccessible fluorocyclopropyl compounds in good yields.
Yinpeng Wang, Tao Yang, Marc Taillefer, Alexis Prieto   +3 more
wiley   +1 more source

Highly Resolved Community Sewage Metagenomics Unveiling Landscape and Transmission Patterns of Antibiotic Resistome in Hong Kong Populations

Advanced Science, Volume 13, Issue 20, 9 April 2026.
A large‐scale, high‐resolution antimicrobial resistance (AMR) surveillance in Hong Kong community sewage combining short‐ and long‐read sequencing. The resistome profile is comprehensively characterized, and this upstream sampling strategy demonstrated superiority in reflecting the human gut resistome.
Jiahui Ding, Mengying Wang, Xiaoqing Xu, Dou Wang, Xi Chen, Shuxian Li, Xiawan Zheng, You Che, Yu Deng, Tommy T. Y. Lam, Liguan Li, Tong Zhang   +11 more
wiley   +1 more source

Effects of Supramolecular Interactions on E/Z‐Isomerizations in Water and Their Importance for Biological Applications

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
Biomimetic supramolecular hosts in water affect outcomes and behavior of E/Z‐isomerizations. A deeper understanding of such effects can pave the way to understanding photochemical processes in more complex biological environments. The review displays examples of supramolecular hosts affecting the outcomes of E/Z‐isomerizations and subsequently ...
Doğan Akbulut, Gianna Pölderl, Line Næsborg   +2 more
wiley   +1 more source

Bacteriological Profile and Antibiogram of Neonatal Septicemia

National Journal of Community Medicine, 2012
Background: Early diagnosis and proper management of neonatal septicemia can bring down the morbidity and mortality substantially.4 Hence the aim of this study was to study the bacteriological profile of neonatal septicemia cases and their antibiogram ...
Sima K Bhatt , Disha A Patel , Praveg Gupta , Kiran Patel , Gurudutt Joshi   +4 more
doaj  

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

SÍNTESIS SELECTIVA DEL PRECURSOR DE COMPUESTOS BIOACTIVOS 4-METIL-2-QUINOLONA EMPLEANDO EL REACTIVO DE EATON

Avances en Ciencias e Ingeniería, 2019
In this paper the use of Eaton´s reagent for the selective synthesis of 4-methyl-2-quinolone is described, avoiding the use of mineral acids and expensive metal catalysts such as those described in the literature. This reagent is easily available and has
Gisela C. Muscia, Ayelen Luczywo, Juan P. Carnevale, Graciela Y. Buldain, Silvia E. Asís   +4 more
doaj  

Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster [PDF]

, 2017
Four inhibitors of eukaryotic topoisomerases were investigated for genotoxic effects in the wing spot test of Drosophila melanogaster. As a somatic mutation and recombination test (SMART) this assay assesses mitotic recombination and mutational events of
Frei, Hansjörg, Würgler, Friedrich E.
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