Results 71 to 80 of about 32,766 (293)

Pharmacokinetics and Safety Evaluation of a New Generic Sitafloxacin: A Phase I Bioequivalence Study in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Sitafloxacin is a new antibiotic drug belonging to the fourth generation quinolone antibiotics. The aim of this study was to evaluate the pharmacokinetics (PK), safety profiles, and bioequivalence of test and reference 50‐mg sitafloxacin tablets under fasting and fed conditions.
Yongfang Lei, Pan Luo, Yuzhu Chen, Liuliang Xue, Donglin Zhang, Xingxing Qi, Yinian Fang, Hengyi Yu, Zheng He, Qin Zuo, Chang Liu, Dong Liu, Xinhua Ren, Qian Chen   +13 more
wiley   +1 more source

Comparative study on antagonistic effects of low pH and cation supplementation on in-vitro activity of quinolones and aminoglycosides against Pseudomonas aeruginosa [PDF]

, 2017
The antagonistic effects of physiological levels of Ca++ and Mg++ on the in-vitro activity of aminoglycosides and quinolones against Pseudomonas aeruginosa were studied at both pH 7.4 and 5.5. Adding Mg++ and Ca++ (100 mg/l) to commercial media deficient
Blaser, Jürg, Lüthy, Ruedi
core  

Magnetic Layered Double Hydroxide Nanocomposites: Synthesis, Catalytic Performances, Environmental and Biological Applications

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review involves a comprehensive study on the diverse applications of the magnetic layered double hydroxides (LDHs) including their catalytic performances, as well as, environmental and biological functions. Moreover, different strategies utilized for the synthesis of LDH‐based composites are described.
Mohammad Mavvaji, Ahmed M. Senan, Senem Akkoc   +2 more
wiley   +1 more source

Risk factors for hospitalized patients with resistant or multidrug-resistant Pseudomonas aeruginosa infections: a systematic review and meta-analysis

Antimicrobial Resistance and Infection Control, 2018
Background Identifying risk factors predicting acquisition of resistant Pseudomonas aeruginosa will aid surveillance and diagnostic initiatives and can be crucial in early and appropriate antibiotic therapy.
Gowri Raman, Esther E. Avendano, Jeffrey Chan, Sanjay Merchant, Laura Puzniak   +4 more
doaj   +1 more source

Usual and unusual antibacterial effects of quinolones [PDF]

, 2017
Recently documented antibacterial effects of quinolones are reviewed. DNA gyrase is most likely to be the primary target site for these agents. Quinolones rapidly kill susceptible bacteria; the mechanisms of the bactericidal activity, still poorly ...
Furet, Y. X., Pechère, J.-C
core  

Investigation of the coordination chemistry, biomolecular interactions and cytotoxicity of heterocyclic carboxamide manganese(II) complexes

European Journal of Inorganic Chemistry, Accepted Article.
Reactions of ligands 5‐methyl‐N‐(quinolin‐8‐yl)pyrazine‐2‐carboxamide (L1), N‐( N‐(pyridin‐2‐ylmethyl)pyrazine‐2‐carboxamide (L2), N‐(quinolin‐8‐yl)picolinamide (L3), N‐(quinolin‐8‐yl)quinoline‐2‐carboxamide (L4) with the MnCl2.4H2O salt afforded the respective manganese complexes [Mn(L1)(CH3OH)2Cl] (Mn1), [Mn(L2)2] (Mn2) [Mn(L3)2] (Mn3) and [Mn2(L4)2 ...
Nokwanda Tsaulwayo, Koena L. Moabelo, Mervin Meyer, Stephen O. Ojwach   +3 more
wiley   +1 more source

Enantioselective Anion‐Binding‐Catalyzed Nucleophilic Addition to 4‐Quinolones

European Journal of Organic Chemistry, EarlyView.
The first organocatalytic enantioselective formal 1,4‐addition to 4‐quinolones has been developed. This method relies on chiral triazole‐based anion‐binding catalysis using enol nucleophiles, complementing previous metal catalytic approaches. Moderate to good yields and enantioselectivities were achieved by in situ silylation and formation of a key ...
Martin Aleksiev, Gaukhar Khassenova, Olga García Mancheño   +2 more
wiley   +1 more source

SYNTHESIS AND CHARACTERIZATION OF QUINOLINONES AND BIOLOGICAL ACTIVITY OF SOME SELECTIVE COMPOUNDS [PDF]

, 2016
Quinolinone is a heterocyclic aromatic organic compound. Quinolinone derivatives are having very much usefulness in current therapeutic applications in medicinal chemistry and pharmacology.
Asif, Mohammad
core   +2 more sources

4-Quinolone Alkaloids from Melochia odorata [PDF]

Journal of Natural Products, 2014
The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 μM and inhibition of HIV P24 formation of more than 50%
Michael Koch, Raquel C. Jadulco, Louis R. Barrows, Louis R. Barrows, Teatulohi Matainaho, Teatulohi Matainaho, Osia G. Gideon, Ryan M. Van Wagoner, Pius Piskaut, Christopher D. Pond   +9 more
openaire   +3 more sources

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

Ibrain, EarlyView.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
wiley   +1 more source