Results 31 to 40 of about 3,781 (252)

Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors.
Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed   +11 more
doaj   +1 more source

Tetraaza[7]–[15]helicenes Synthesized by Two‐Step Strategy: Length‐Controlled Chiral π‐Systems Exhibiting Amplified Circularly Polarized Luminescence

Angewandte Chemie, EarlyView.
A modular two‐step strategy provides tetraaza[n]helicenes (n = 7–15) as a homologous series with tunable photophysical and chiroptical properties. Extension beyond n = 11 induces pronounced through‐space π–π interactions, narrowing the energy gap and amplifying circularly polarized luminescence.
Takashi Otani, Yuchen Wu, Kohei Ueda, Yuki Ikeda, Yuna Tada, Natsuna Kinoshita, Takanori Shibata   +6 more
wiley   +2 more sources

Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff\u27s bases incorporating imidazole moiety as potential antimicrobial agents [PDF]

, 2015
(1,4,5-Triphenylimidazol-2-yl-thio)butyric acid hydrazide (3) was obtained via alkylation of 1,4,5-triphenylimidazol-2-thiol (1) with ethylbromobutyrate, followed by addition of hydrazine hydrate. Treatment of acid hydrazide 3 with carbon disulfide in an
ADEEB AL-SHEIKH ALI, ALAIN LESIMPLE, MOHAMED REDA AOUAD, MOUSLIM MESSALI, NADJET REZKI   +4 more
core   +3 more sources

Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity [PDF]

, 2012
Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of
Alok Pandey, Deepak Dash, R. Rajavel, Sandeep Chandraker   +3 more
core   +2 more sources

Bazı piridin türevi 1,3,4-tiyadiazol bileşiklerinin eldesi ve mikrobiyolojik özelliklerinin incelenmesi [PDF]

, 2021
Piridin karboksilik asit türevleri ile iki farklı tiyosemikarbazid türevi arasındaki reaksiyondan dokuz yeni 1,3,4 tiyadiazol bileşiği sentezlendi. Sentezlenen bileşiklerin yapıları, 1 H-NMR, FT-IR gibi spektroskopik yöntemlerle ve element analizi ...
Aldwıb, Aıman Emhemad Omeran
core   +1 more source

Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)-4-carbonitrile

Molbank, 2023
Electron-withdrawing heterocyclic units are found in most organic optoelectronic materials. Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) is an interesting new heterocyclic system, the chemical properties of which are much less studied than other fused ...
Timofey N. Chmovzh, Timofey A. Kudryashev, Karim S. Gaisin, Oleg A. Rakitin   +3 more
doaj   +1 more source

Design, synthesis, characterization and computational docking studies of novel sulfonamide derivatives [PDF]

This study reports three novel sulfonamide derivatives 4-Chloro-N-[(4-methylphenyl) sulphonyl]-N-propyl ben- zamide (1A), N-(2-hydroxyphenyl)-4-methyl benzene sulfonamide (1B) and 4-methyl-N-(2-nitrophenyl) ben- zene sulfonamide (1C).
Ashiq, Ayesha, Bokhari, Saleem Ahmed, Khalid, Rana Rehan, Maryam, Arooma, Qureshi, Fahim Ashraf, Rauf, Sadaf Abdul, Saleem, Hira, Siddiqi, Abdul Rauf   +7 more
core   +1 more source

Utility of 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity

BMC Chemistry, 2019
Background Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores with a wide range of biological ...
Abdou O. Abdelhamid, Ibrahim E. El Sayed, Yasser H. Zaki, Ahmed M. Hussein, Mangoud M. Mangoud, Mona A. Hosny   +5 more
doaj   +1 more source

Triazolo [3, 4-b] [1, 3, 4] thiadiazoles

, 1982
Chemistry Department, Panjab University, Chandigarh- 160 014 Manuscript received 29 September 1981, accepted 11 March 1982 Triazolo [3, 4-b] [1, 3, 4 ...
H. K. GAKHAR, ANJU JAIN, SHASHI BHUSHAN GUPTA   +2 more
openaire   +1 more source

The Preparation and Characterization of 5-Substituted-4-chloro-1,2,3-dithiazolium Salts and their Conversion into 4-Substituted-3-chloro-1,2,5-thiadiazoles

Molecules, 2005
A series of monosubstituted acetonitriles were treated with disulfur dichloride atroom temperature in CH2Cl2 to afford 5-substituted-4-chloro-1,2,3-dithiazolium chlorides 1.Where the 5-substituent was not a good leaving group the chloride salts were ...
P. Koutentis
doaj   +1 more source