Results 41 to 50 of about 9,296,901 (229)
Triazolo [3, 4-b] [1, 3, 4] thiadiazoles
, 1982 Chemistry Department, Panjab University, Chandigarh- 160 014 Manuscript received 29 September 1981, accepted 11 March 1982 Triazolo [3, 4-b] [1, 3, 4 ...
H. K. GAKHAR +2 more
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An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity
Advanced Science, EarlyView.The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao +9 more
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A COMPUTATIONAL STUDY OF SUBSTITUENT EFFECT 1, 3, 4-THIADIAZOLE ON CORROSION INHIBITION
Azerbaijan Chemical Journal, 2023 A theoretical study of 1, 3, 4-thiadiazole with nine various derivatives in gaseous and aqueous phases was investigated by employing the density functional theory (DFT) at 6-311++(d, p) basis set and Becke’s three parameters hybrid exchange-correlation functional (B3LYP).
Mohammad Qadr Hiwa, Mustafa Mamand Dyari
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Dual‐Module Near‐Infrared Fluorophores Discovery System via Knowledge Transfer
Advanced Science, EarlyView.This study presents a dual‐module deep learning system for the design of near‐infrared (NIR) fluorophores. A large molecular library is generated and analyzed, leading to the suggestions of promising candidates. The effectiveness of the system is further validated through the synthesis, characterization, and in vivo imaging, demonstrating its potential
Yixin Zhu +7 more
wiley +1 more source
BMC Chemistry, 2019 Background Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores with a wide range of biological ...
Abdou O. Abdelhamid +5 more
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Molecules, 2005 A series of monosubstituted acetonitriles were treated with disulfur dichloride atroom temperature in CH2Cl2 to afford 5-substituted-4-chloro-1,2,3-dithiazolium chlorides 1.Where the 5-substituent was not a good leaving group the chloride salts were ...
P. Koutentis
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Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
, 2006 A series of new Schiff bases were synthesized through the condensation reaction of 1,3,4-thiadiazoles containing a aromatic primary amine and 3-hydroxybenzaldehyde, salicylaldehyde, 5-nitrofurfuraldehyde or 3-nitrobenzaldehyde.
core +2 more sources
Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)-4-carbonitrile
Molbank, 2023 Electron-withdrawing heterocyclic units are found in most organic optoelectronic materials. Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) is an interesting new heterocyclic system, the chemical properties of which are much less studied than other fused ...
Timofey N. Chmovzh +3 more
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Novel Synthetic Derivatives of Substituted Amino -1, 2, 4-Thiadiazoles
International Journal of Chemical and Physical Sciences, 2012 A novel series of 3-amino-5-substituted amino-1,2,4-thiadiazoles (5a-f) and 3substituted thiocarbamido-5-substituted amino-1,2,4-thiadiazoles (6a-f) have been obtained by the oxidative cyclization of 1-substituted-3-formamidinothiocarbamide 1 (3af) and 1,3-bis(substitutedthioamido)-guanidine 1 (4a-f) with bromine respectively.
M.E. Shelke, J.S. Waghmare
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